The landers trunkless temporary keratoprosthesis.

Objective: To demonstrate the watertight seal created by the new wide-angle Landers trunkless temporary keratoprosthesis (T-TKP).

Methods: In 20 enucleated, porcine eyes, a 7.5-mm trephination was made, followed by capsulorrhexis and lensectomy.

Maintaining a watertight globe while operating with a temporary keratoprosthesis.

Purpose: To demonstrate that the Landers wide-field temporary keratoprosthesis (TKP) creates a watertight seal between the tightly opposing surfaces of the TKP flange and the anterior corneal surface.

Methods: In 25 and 20 enucleated, porcine eyes, a 7.5-mm and 8.

Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging.

Purpose: To prospectively identify brain regions in which task-related changes in activation during a memory encoding task, measured with functional magnetic resonance (MR) imaging, correlate with degree of memory impairment across Alzheimer disease (AD), mild cognitive impairment (MCI), and elderly control subjects.

Materials And Methods: The institutional review board approved this HIPAA-compliant study, and each patient gave written informed consent. Seventy-five subjects (mean age, 72.

Hippocampal volume and the Mini-Mental State Examination in the diagnosis of amnestic mild cognitive impairment.

Objective: The purpose of this study was to examine the diagnostic efficacy of hippocampal volumetry and the Mini-Mental State Examination (MMSE) in differentiating amnestic mild cognitive impairment from the normal changes of aging.

Subjects And Methods: The conditions of healthy older persons (n = 17) and persons with amnestic mild cognitive impairment (n = 18) were classified on the basis of results of comprehensive neuropsychological assessment. All subjects underwent MRI at 4 T, including high-resolution coronal T1-weighted images.

Mild cognitive impairment: evaluation with 4-T functional MR imaging.

Purpose: To prospectively assess abnormalities in brain activation patterns during encoding and retrieval in subjects with mild cognitive impairment by using 4-T functional magnetic resonance (MR) imaging.

Materials And Methods: The institutional review board approved this HIPAA-compliant study; all subjects gave written informed consent. Twenty patients with mild cognitive impairment (12 men, eight women; mean age, 75.

Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders.

Functional magnetic resonance imaging (fMRI) studies in memory impairment have detected functional alterations in medial temporal lobe (MTL) structures, notably the hippocampus. Many of these studies employ spatial normalization to place subjects in a standardized template space prior to analysis; however, little is known about the effects of local atrophy on the normalization process in structures such as the hippocampus. The purpose of this study was to compare the accuracy of spatial normalization of the hippocampus between memory-impaired patients and controls.

Screening for Early Alzheimer's Disease: Is There Still a Role for the Mini-Mental State Examination?

Background: The objective of this study was to compare the performance of the Mini-Mental State Examination (MMSE) total score as well as item scores in separating 4 groups of elderly (55-85 years of age) subjects-normal controls, subjects with mild cognitive impairment (MCI), subjects with mild Alzheimer's disease, and subjects with depression.Method: The MMSE scores of 86 subjects (25 normal elderly controls, 26 subjects with MCI, 10 subjects with mild Alzheimer's disease, and 25 subjects with depression) were analyzed. Statistically significant differences between groups in both overall MMSE score and individual item scores were documented.