Publications by authors named "Thanh-Thanh Thi Nguyen"
Developing and validating noninvasive prenatal testing for autosomal dominant monogenic diseases in Vietnam.
Nhi Yen Nguyen Y-Thanh Lu Duy-Anh Nguyen Canh-Chuong Nguyen Linh Thuy Dinh Vu Quoc Huy Nguyen Van Thong Nguyen My-Nhi Ba Nguyen My-Ngoc Ba Nguyen Minh-Trung Nguyen Thanh-Thanh Thi Nguyen Hoai-Nghia Nguyen
Per Med
September 2023
Over 60% of single-gene diseases in newborns are autosomal dominant variants. Noninvasive prenatal testing for monogenic conditions (NIPT-SGG) is cost-effective and timesaving, but not widely applied. This study introduces and validates NIPT-SGG in detecting 25 monogenic conditions.
View Article and Find Full Text PDFHigh prevalence of maternal mosaic monosomy X in pregnant women in Vietnam.
Danh Cuong Tran Thanh-Thanh Thi Nguyen Ngoc-Lan Thi Hoang Lan-Anh Thi Luong Kim-Phuong Thi Doan Van-Thong Nguyen Ngoc-Trinh Kieu Nguyen Cong-Trai Nguyen Thanh-Dat Nguyen xQuynh-Tho Thi Nguyen Hoai-Nghia Nguyen
J Matern Fetal Neonatal Med
December 2023
Article Synopsis
- The study aimed to assess the prevalence of maternal mosaic monosomy X (MMXO) among pregnant women in Vietnam using noninvasive prenatal screening methods.
- Out of over 105,000 women analyzed, 295 were suspected of having MMXO, with further testing confirming 125 cases, resulting in a confirmed prevalence of 0.118%.
- The results indicate that MMXO significantly affects chromosome X measurements, leading to many false positives when using size-based methods, while the count-based method is better for accurate results.
Combined Gap-Polymerase Chain Reaction and Targeted Next-Generation Sequencing Improve α- and β-Thalassemia Carrier Screening in Pregnant Women in Vietnam.
Tuan-Thanh Lam Doan-Tu Nguyen Quang Thanh Le Duy-Anh Nguyen Diem-Tuyet Thi Hoang Huu Du Nguyen Canh Chuong Nguyen Van Thong Nguyen Xuan Thao Nguyen Van Trong Nguyen Hoai Thanh Nguyen Manh Hoan Nguyen Duy-Khang Nguyen Le Thien-Chi Van Nguyen Thanh-Thanh Thi Nguyen Thanh-Phuong Thi Nguyen Cong-Trai Nguyen Thanh-Dat Nguyen Hoai-Nghia Nguyen
Hemoglobin
July 2022
Article Synopsis
- Vietnam has a significant thalassemia issue, with a study of 5,880 pregnant women revealing a 13.13% carrier frequency for thalassemia.
- The breakdown of carriers included 7.82% for α-thalassemia and 5.31% for β-thalassemia, with common mutations identified in both types.
- The study highlights the effectiveness of combining next-generation sequencing with gap-PCR for comprehensive thalassemia screening, estimating that around 5,021 babies could be born with severe thalassemia in Vietnam each year.
Ultra-Deep Massive Parallel Sequencing of Plasma Cell-Free DNA Enables Large-Scale Profiling of Driver Mutations in Vietnamese Patients With Advanced Non-Small Cell Lung Cancer.
Le Son Tran Quynh-Tho Thi Nguyen Chu Van Nguyen Vu-Uyen Tran Thai-Hoa Thi Nguyen Mai-Lan Thi Nguyen Luan Thanh Nguyen Thien-Chi Van Nguyen Long Hung Nguyen Thanh-Thanh Thi Nguyen Kim-Huong Thi Nguyen Nguyen Huu Nguyen Hoai-Nghia Nguyen
Front Oncol
August 2020
Article Synopsis
- Population-specific profiling of cancer gene mutations is essential for better understanding cancer biology and improving diagnostics and treatment tailored to specific groups.
- The study used ultra-deep massive parallel sequencing of plasma cell-free DNA (cfDNA) to analyze mutations in 265 Vietnamese patients with advanced non-small cell lung cancer, offering a less invasive alternative to traditional tumor tissue analysis.
- Although cfDNA testing had lower mutation detection rates, it still identified major mutations in key driver genes that were consistent with findings from tissue sample analysis, highlighting its potential for large-scale genetic profiling in populations with limited access to tumor biopsies.