The T cell receptor β chain repertoire of tumor infiltrating lymphocytes improves neoantigen prediction and prioritization.

In the realm of cancer immunotherapy, the meticulous selection of neoantigens plays a fundamental role in enhancing personalized treatments. Traditionally, this selection process has heavily relied on predicting the binding of peptides to human leukocyte antigens (pHLA). Nevertheless, this approach often overlooks the dynamic interaction between tumor cells and the immune system.

Improvement in neoantigen prediction via integration of RNA sequencing data for variant calling.

Introduction: Neoantigen-based immunotherapy has emerged as a promising strategy for improving the life expectancy of cancer patients. This therapeutic approach heavily relies on accurate identification of cancer mutations using DNA sequencing (DNAseq) data. However, current workflows tend to provide a large number of neoantigen candidates, of which only a limited number elicit efficient and immunogenic T-cell responses suitable for downstream clinical evaluation.

An adaptive weighting mechanism for Reynolds rules-based flocking control scheme.

Cooperative navigation for fleets of robots conventionally adopts algorithms based on Reynolds's flocking rules, which usually use a weighted sum of vectors for calculating the velocity from behavioral velocity vectors with corresponding fixed weights. Although optimal values of the weighting coefficients giving good performance can be found through many experiments for each particular scenario, the overall performance could not be guaranteed due to unexpected conditions not covered in experiments. This paper proposes a novel control scheme for a swarm of Unmanned Aerial Vehicles (UAVs) that also employs the original Reynolds rules but adopts an adaptive weight allocation mechanism based on the current context than being fixed at the beginning.