Iodine-promoted amide formation oxidative cleavage of indoles: novel quinazoline-4(3)-one and tryptanthrin syntheses.

A highly efficient method for the direct construction of amide bonds a selective cleavage of C-H and C[double bond, length as m-dash]C bonds in indole structures using an iodine-promoted approach was developed. Mechanistic studies indicated the formation of superoxide radicals obtained from molecular oxygen activation as a key intermediate step, which provided a precursor for subsequent oxidative ring-opening and intermolecular cyclization. A broad range of quinazolin-4(3)-ones and tryptanthrins were synthesized in moderate to good yields under mild and environmentally benign conditions.

A study of the impact of an interprofessional education module in Vietnam on students' readiness and competencies.

Introduction: The literature puts forward a range of challenges of interprofessional education (IPE) related to its planning, initiation, implementation, and especially to IPE assessment. The present study aims to map changes in students' readiness and interprofessional collaboration competence (IPCC) in implementing an innovative IPE module. Potential differences in impact related to the health education programs and IPCC scores resulting from self-, peer-, and tutor assessments will also be analysed.