Publications by authors named "Thanh Tung Le"

Atherosclerotic cardiovascular diseases (CVDs) are closely linked to factors such as familial hypercholesterolemia (FH), often caused by mutations in low-density lipoprotein receptor () and apolipoprotein B (). Through a comprehensive bioinformatic analysis, we identified novel and mutations and their cardiovascular disease (CVD) implications, focusing on unique variants in the Vietnamese population. We used homology modeling to predict protein structures; in addition, through protein-protein molecular docking, we assessed how these mutations affect binding affinities.

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Four strains of green microalgae (, , , and ) were compared to determine growth and pigment composition under photoautotrophic or heterotrophic conditions. Batch growth experiments were performed in multicultivators with online monitoring of optical density. For photoautotrophic growth, light-limited (CO-sufficient) growth was analyzed under different light intensities during the exponential and deceleration growth phases.

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Background: In developing countries, fewer women have access to multidisciplinary congenital heart disease and reproductive programs staffed by experts. We report pregnancy outcomes of a multidisciplinary healthcare strategy utilizing an in-hospital teamwork approach in Vietnam.

Methods: This retrospective cohort study included pregnant women with unrepaired congenital heart disease managed at a referral cardiovascular center.

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Background And Aims: Recent studies have highlighted the increased risk of low bone mineral density (BMD) in adults with cardiovascular disease. However, little is known about BMD in adults with congenital heart disease (CHD), particularly in developing countries. We hypothesized that factors related to BMD would lead to a high prevalence of low BMD in adults with CHD.

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Considering the importance of microalgae as a promising feedstock for the production of both low- and high-value products, such as lipids and pigments, it is desirable to isolate strains which simultaneously accumulate these two types of products and grow in various conditions in order to widen their biotechnological applicability. A novel freshwater strain from the genus was isolated in Belgium. Compared to other species, the isolate presented rapid growth in phototrophy, dividing 3.

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Background: Little is known about the quality of life (QOL) and health status of adults with congenital heart disease (CHD) in developing countries. Therefore, this study aimed to describe the QOL and health status of hospitalized adults with CHD in Vietnam and investigate the association between QOL and their biological-social characteristics.

Methods: A cross-sectional study was conducted with 109 adults with CHD, hospitalized in the Vietnam National Heart Institute, between June and December 2019.

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Familial hypercholesterolemia (FH) is underdiagnosed and undertreated in a majority of the low- and middle-income countries. FH registries could prove useful in bridging the knowledge gaps, supporting genetic and clinical research, and improving health-care planning and patient care. Here, we report the first usage experience of the Vietnam FH (VINAFH) Registry.

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Hollow heterostructures have tremendous advantages in electrochemical energy storage and conversion areas due to their unique structure and composition characteristics. Here, we report the controlled synthesis of hollow CoSe nanocubes decorated with ultrathin MoSe nanosheets (CoSe@MoSe) as an efficient and robust bifunctional electrocatalyst for overall water splitting in a wide pH range. It is found that integrating ultrathin MoS nanosheets with hollow CoSe nanocubes can provide abundant active sites, promote electron/mass transfer and bubble release and facilitate the migration of charge carriers.

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One-dimensional (1D) heterostructured photocatalysts with controllable texture properties and compositions have attracted increasing interest owing to their unique optical, structural, and electronic advantages. Herein, 1D CoO-SnO heteronanorods were rationally designed and synthesized through a facile solution-based approach. Benefiting from both of their heterostructural and compositional characteristics, the resulting CoO-SnO heteronanorods exhibit high photocatalytic performance for the degradation of Rhodamine B (RhB) under visible-light irridation.

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Construction of heterostructures with proper band alignment and effective transport and separation of photogenerated charges is highly expected for photocatalysis. In this work, Ni-doped SnO-SnS heterostructures (NiSnSO) are simply prepared by thermal oxidation of Ni-doped hierarchical SnS microspheres in the air. When applied for the photodegradation of organic contaminants, these NiSnSO exhibit excellent catalytic performance and stability due to the following advantages: (1) Ni doping leads to the enhancement of light harvesting of SnS in the visible light regions; (2) the formed heterojunctions promote the transport and separation of photogenerated electrons from SnS to SnO; (3) Ni-SnO quantum dots facilitate the enrichment of reactants, provide more reactive centers and accelerate product diffusion in the reactive centers; (4) the SnS hierarchical microspheres constituted by nanoplates provide abundant active sites, high structural void porosity and accessible inner surface to faciliate the catalytic reactions.

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