Publications by Thanh Nhan Vo Nguyen

Publications by authors named "Thanh Nhan Vo Nguyen"

The study introduces a new assay called SPOT-MAS that combines multiple analysis techniques to detect different types of cancer using circulating tumor DNA (ctDNA).
SPOT-MAS was tested on a large group of 738 patients with various cancers and 1550 healthy controls, successfully identifying cancers with a sensitivity of 72.4% and high specificity.
The assay performs well for early-stage cancers and shows promise for being more cost-effective compared to other ctDNA tests due to its lower sequencing depth requirements.

BMC Cancer

March 2023

- Late detection of hepatocellular carcinoma (HCC) leads to a low survival rate, but liquid biopsy assays that detect circulating tumor DNA (ctDNA) offer a potential early non-invasive detection method; however, challenges exist due to normal cell mutations and tumor diversity.
- Researchers developed a classification model using deep sequencing of 13 HCC-associated genes, analyzing ctDNA fragment length profiles to distinguish between HCC patients and healthy individuals.
- The model demonstrated strong performance in identifying HCC, with an AUC of 0.88 and 89% sensitivity in the discovery cohort, and similar results in an independent validation cohort, indicating potential for further clinical studies.

Future Oncol

December 2022

* Researchers identified unique methylation markers from cell-free DNA of HCC patients and used them to train machine learning models, which successfully differentiated HCC patients from high-risk individuals without the cancer in testing.
* By integrating these methylation markers with existing serum biomarkers in a commercial test, they achieved improved detection accuracy for HCC, demonstrating potential for early diagnosis.