Lipin knockdown in pan-neuron of Drosophila induces reduction of lifespan, deficient locomotive behavior, and abnormal morphology of motor neuron.

The Lipin family is evolutionarily conserved among insects and mammals, and its crucial roles in lipid synthesis and homeostatic control of energy balance have been well documented. This study investigated the function of Lipin in neuronal function and neurodegeneration. The GAL4/UAS system was used to knock down Lipin in the nervous system of Drosophila and investigate its behavioral and cellular phenotypes.

Antihyperglycemic and anti-type 2 diabetic activity of marine hydroquinone isolated from brown algae ().

Background And Aims: Brown algae () extract (DP) presented high inhibitory potential against α-amylase. The present study aims to isolate, purify and evaluate the antihyperglycemic and anti-type 2 diabetic activities of marine hydroquinone from DP.

Methods: Marine hydroquinones were isolated using silica gel, HPLC, and NMR spectroscopy was used to identify compound 1 and compound 2 as zonarol and isozonarol, respectively.

Drosophila model for studying the link between lipid metabolism and development.

Developmental processes are cascades of biological changes linked with information transfer, growth, and differentiation during the life cycle of an organism. Lipid metabolism plays a vital role in the life cycle of organisms. models grant numerous advantages in investigating the underlying mechanisms of each process as well as their connections.

The Function of Lipin in the Wing Development of .

Lipin is evolutionarily conserved from yeast to mammals. Although its roles in lipid metabolism in adipocyte tissue, skeletal muscle, and the liver, and as a transcriptional co-activator are known, its functions during development are still under investigation. In this study, we analyzed the role of lipin (dLipin) in development.