Publications by authors named "Thanh Lai Nguyen"
Different Biocompatibility and Radioprotective Activity of Squid Melanin Nanoparticles on Human Stromal Cells.
Le-Na Thi Nguyen Xuan-Hai Do Hanh B Pham Dinh Duy-Thanh Uyen Thi Trang Than Thu-Huyen Nguyen Van-Ba Nguyen Dinh-Thang Nguyen Phuc Trong Nguyen Thanh Lai Nguyen Toan D Nguyen Nga Thi Hang Nguyen
ACS Omega
September 2024
Article Synopsis
- The study investigated the biocompatibility of squid ink melanin nanoparticles (NPs) on various human stromal cells and zebrafish embryos, finding they are generally non-toxic and compatible.
- The NPs did not induce cell aging or affect cell movement in human fibroblasts and stem cells, but they hindered tube formation in endothelial cells at certain concentrations.
- In zebrafish embryos, melanin NPs were shown to be safe, indicating potential for use in biomedical applications, particularly in contexts involving radiation exposure.
Among mitotic kinases, Aurora kinases are the most widely studied, since their expression is restricted to mitosis. They play a key role in chromosome segregation and cell polyploidy. Aurora kinases are important therapeutic targets, and several research groups have directed their efforts toward the identification of kinase inhibitors.
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