Publications by authors named "Thanh Huong Thi Tran"
Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization.
Van Thien Chi Nguyen Trong Hieu Nguyen Nhu Nhat Tan Doan Thi Mong Quynh Pham Giang Thi Huong Nguyen Thuy Thi Thu Tran Trung Hieu Tran Anh Minh Tran Quang Dat Tran Thuy Trang Tran Ngan Chau Tran Thanh Huong Thi Tran Duc Huy Tran Thi Minh Thu Tran Thi Trang Tran Vu Uyen Tran Le Son Tran
Elife
October 2023
Article Synopsis
- The study introduces a new assay called SPOT-MAS that combines multiple analysis techniques to detect different types of cancer using circulating tumor DNA (ctDNA).
- SPOT-MAS was tested on a large group of 738 patients with various cancers and 1550 healthy controls, successfully identifying cancers with a sensitivity of 72.4% and high specificity.
- The assay performs well for early-stage cancers and shows promise for being more cost-effective compared to other ctDNA tests due to its lower sequencing depth requirements.
Fragment length profiles of cancer mutations enhance detection of circulating tumor DNA in patients with early-stage hepatocellular carcinoma.
Van-Chu Nguyen Trong Hieu Nguyen Thanh Hai Phan Thanh-Huong Thi Tran Thu Thuy Thi Pham Que-Tran Bui Nguyen Vu Uyen Tran Thuy Thi Thu Tran Le Son Tran
BMC Cancer
March 2023
Article Synopsis
- - Late detection of hepatocellular carcinoma (HCC) leads to a low survival rate, but liquid biopsy assays that detect circulating tumor DNA (ctDNA) offer a potential early non-invasive detection method; however, challenges exist due to normal cell mutations and tumor diversity.
- - Researchers developed a classification model using deep sequencing of 13 HCC-associated genes, analyzing ctDNA fragment length profiles to distinguish between HCC patients and healthy individuals.
- - The model demonstrated strong performance in identifying HCC, with an AUC of 0.88 and 89% sensitivity in the discovery cohort, and similar results in an independent validation cohort, indicating potential for further clinical studies.