Clinical Outcomes of an Asymmetric Model of Intrastromal Corneal Ring Segments for the Correction of Keratoconus.

Purpose: To evaluate the clinical outcomes of a new model of intrastromal corneal ring segments (ICRSs) (Keraring AS) in patients with keratoconus and quantify subsequent changes in refraction and corneal topography.

Methods: This nonrandomized, single-center, retrospective observational study explores the effect of progressive thickness ICRS implantation in patients with keratoconus with a 3-month follow-up. After creating an intrastromal tunnel using a femtosecond laser, 1 or 2 ICRSs of progressive thicknesses (150/250 μm or 200/300 μm) and 160-degree arc length were implanted.

Corneal elevation topography: best fit sphere, elevation distance, asphericity, toricity, and clinical implications.

Purpose: To describe the effect of the corneal asphericity and toricity on the map patterns and best fit sphere (BFS) characteristics in elevation topography.

Methods: The corneal surface was modeled as a biconic surface of principal radii and asphericity values of r1 and r2 and Q1 and Q2, respectively. The apex of the biconic surface corresponded to the origin of a polar coordinates system.

Assessment of patient satisfaction with outcomes of and ophthalmic care for cataract surgery.

Purpose: To assess patient satisfaction with cataract surgery care.

Setting: Private and public health ophthalmic centers, France.

Methods: This prospective longitudinal multicenter observational study enrolled patients attending consultation for a preoperative visit from September 2007 to February 2008.

Comparison of corneal and total ocular aberrations before and after myopic LASIK.

Purpose: To assess the compensation of total ocular and corneal wavefront aberrations after conventional myopic LASIK.

Methods: This study comprised 57 eyes of 57 patients. Total and corneal aberrations were measured preoperatively and 3 months postoperatively using the OPD-Scan (NIDEK Co Ltd) aberrometer.

Corneal hysteresis measured with the Ocular Response Analyzer in normal and glaucomatous eyes.

Purpose: To identify differences in corneal hysteresis (CH) and central corneal thickness (CCT) between healthy and glaucomatous patients.

Methods: Retrospective observational study. One hundred and thirty-three eyes of 75 healthy and 58 glaucomatous patients were included.

Vision-related function after scleral lens fitting in ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis.

Purpose: To describe the therapeutic benefits of scleral lenses in the management of severe ocular surface disease attributable to toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS).

Design: Retrospective study.

Methods: Clinical records of 39 patients (67 eyes) fitted with scleral lenses for refractory ocular surface disease attributable to SJS or TEN were reviewed.

Comparison of and correlation between anterior and posterior corneal elevation maps in normal eyes and keratoconus-suspect eyes.

Purpose: To compare the anterior and posterior corneal elevation maps between keratoconus-suspect eyes and normal eyes.

Setting: Rothschild Foundation, AP-HP, University Paris VII, Hôpital Bichat Claude Bernard, Paris, France.

Methods: The anterior and posterior corneal surface elevations were analyzed and compared in 60 normal myopic patients and 48 keratoconus-suspect patients.

Objective assessment of the quality of vision before and after repositioning of a dislocated iris-fixated aphakic anterior chamber lens.

Purpose: To document severe visual symptoms due to the dislocation of an iris-fixated aphakic anterior chamber lens using wavefront aberrometry.

Methods: A patient complaining of severe visual blur and distortion due to a decentered Artisan iris-fixated anterior chamber lens was evaluated pre- and postoperatively after recentration. The patient underwent complete ophthalmic evaluation including the measurement of corneal topography and wavefront aberrations using the NIDEK OPD-Scan.

Geometric customization of optical and transition zone parameters for treatment of compound myopic astigmatism with the NIDEK EC-5000 excimer laser.

Purpose: To compare the refractive outcome of two ablation zone designs using LASIK for the correction of compound myopic astigmatism.

Methods: This retrospective study compared refractive outcomes in two groups of patients undergoing LASIK. In the circular treatment group, 45 eyes were corrected with circular optical and transition zones of 6 mm and 6.

Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling.

Extracellular matrix metalloproteinase inducer (EMMPRIN) is a cell surface glycoprotein enriched on tumor cells and normal epithelia. It is mainly known for its ability to induce matrix metalloproteinase production in fibroblasts following epithelial-stromal interaction. We sought to examine whether EMMPRIN has a broader role promoting fibroblast-to-myofibroblast differentiation.

Contribution of the corneal epithelium to anterior corneal topography in patients having myopic photorefractive keratectomy.

Purpose: To assess the variations in corneal topographic characteristics after removal of the epithelium in patients having myopic photorefractive keratectomy (PRK).

Setting: Rothschild Foundation, Paris, France.

Methods: Forty-four eyes of 25 patients with myopia had corneal topography examination with the Orbscan II device (Bausch & Lomb) before removal of the corneal epithelium preoperatively and after removal of the corneal epithelium during PRK.

Measurement of combined corneal, internal, and total ocular optical quality analysis in anterior segment pathology with the OPD-scan and OPD-station.

Purpose: To show the clinical use of the NIDEK OPD-Scan wavefront aberrometer and OPD-Station software in anterior segment surgery and pathology.

Methods: Case examples are presented along with discussion about the relevant clinical data obtained from the OPD-Scan and OPD-Station software.

Results: Six case examples including cataract surgery, secondary IOL implantation, phakic intraocular lens surgery, pterygium surgery, contact lens fitting, and multifocal ablations are discussed.

Archipelago keratitis: a clinical variant of recurrent herpetic keratitis?

Objective: To describe archipelago keratitis, a presumed clinical variant of herpetic epithelial keratitis.

Design: Case series.

Participants: A series of 6 patients with an unusual form of superficial keratitis.

Long-term visual outcome of childhood blepharokeratoconjunctivitis.

Purpose: To assess the visual outcome of childhood blepharokeratoconjunctivitis.

Design: Retrospective noncomparative case series.

Methods: We reviewed visual acuity and corneal examination results for 23 patients (mean age 19 +/- 4 years, range, 11 to 26 years) who had healed more than three years previously (up to 15 years).

Corneal hysteresis, resistance factor, topography, and pachymetry after corneal lamellar flap.

Purpose: To measure prospectively the early changes in corneal hysteresis, topography, and pachymetry after the creation of a stromal flap cut without laser photoablation.

Methods: A 37-year-old man was referred for a bioptic procedure to correct for compound myopic astigmatism in the left eye. A 159-microm-thick 8x8.

Ocular aberrations after cataract surgery with hydrophobic and hydrophilic acrylic intraocular lenses: comparative study.

Purpose: To compare tilt and some higher-order aberrations (HOAs) in patients who had cataract surgery and implantation of 2 types of acrylic intraocular lens (IOL), the hydrophobic MA60AC (Alcon) or the hydrophilic XLSTABI (Ioltech).

Setting: Fondation Ophtalmologique Adolphe de Rothschild, Department of Pr Hoang-Xuan, Paris, France.

Methods: Sixty eyes were included in this study.

Topical cyclosporine A in severe steroid-dependent childhood phlyctenular keratoconjunctivitis.

Purpose: To assess the efficacy of topical cyclosporine A (CsA) in children with phlyctenular keratoconjunctivitis associated with severe steroid-dependent corneal inflammation.

Design: Prospective, noncomparative, interventional case series.

Methods: patients: Children with phlyctenular keratoconjunctivitis associated with severe steroid-dependent corneal inflammation and not responding to oral antibiotics (cyclines or erythromycin).

Role of hyaluronidase in diplopia after peribulbar anesthesia for cataract surgery.

Objective: To determine the protective action of hyaluronidase on peribulbar anesthesia-related diplopia in patients undergoing cataract surgery.

Design: Single-center observational case series.

Participants: All patients undergoing elective phacoemulsification and intraocular lens implantation under peribulbar anesthesia between February 2001 and January 2003.

EMMPRIN/CD147, an MMP modulator in cancer, development and tissue repair.

Matrix metalloproteinases (MMPs) play a central role in normal tissue remodeling and disease, they regulate tumor microenvironment and their expression is increased in most human cancers. Targeting their activity remains a major challenge. Their production and activation is tightly regulated by complex mechanisms that include cytokines and growth factors, cell-matrix and cell-cell interactions.

Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.

Extracellular matrix metalloproteinase inducer (EMMPRIN) was originally identified on the tumor cell surface as an inducer of matrix metalloproteinase (MMP) production in neighboring fibroblasts. Here we demonstrate a role for EMMPRIN in MMP induction during corneal wound healing. MMP and EMMPRIN expression was analyzed in normal and ulcerated human corneas, as well as in corneal epithelial and stromal cells in culture using confocal microscopy, zymography, immunoblots, and real-time polymerase chain reaction.

Corneal asphericity change after excimer laser hyperopic surgery: theoretical effects on corneal profiles and corresponding Zernike expansions.

Purpose: To determine the theoretical relationships between the changes in corneal paraxial power, asphericity, and the corresponding Zernike polynomial expansion after conventional and customized excimer laser correction of hyperopia.

Methods: The initial corneal profile was modeled as a conic section of apical radius of curvature R1 and asphericity Q1. The theoretical value of the postoperative apical radius of curvature R2 was computed by using a paraxial formula from the value of R1 and hyperopic defocus D.

Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases.

Objective: To report a case of a 50-year-old man who was initially seen with a corneal perforation in his right eye 2 months after a photorefractive keratectomy (PRK) procedure and to discuss the roles of topical diclofenac and matrix metalloproteinases (MMPs).

Design: Case report with tissue analysis.

Main Outcome Measures: Ocular examination, diagnostic workup, surgical treatment, and histologic, immunofluorescent, zymography, and real time-polymerase chain reaction studies on corneal button.

Limbal stem cell deficiency following phototherapeutic keratectomy.

Purpose: To describe a case of limbal stem cell (LSC) deficiency following phototherapeutic keratectomy (PTK).

Methods: We analyzed the case of a 67-year-old man who developed LSC deficiency in his left eye following PTK for recurrent epithelial erosions. Predisposing factors included diabetes mellitus and rosacea.

Reliability of pachymetric measurements using orbscan after excimer refractive surgery.

Purpose: To assess the accuracy of pachymetric measurements using Orbscan (Bausch & Lomb, Rochester, NY) after laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK).

Design: Prospective instrument validation study.

Participants: Seventy-nine nonoperated normal eyes, 84 eyes after LASIK, and 50 eyes after PRK.