Publications by authors named "Thanh Ho Ngoc Dan"
Background: Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, is a major public health problem in low- and middle-income countries. Moderate sensitivity and scalability of current methods likely underestimate enteric fever burden. Determining the serological responses to organism-specific antigens may improve incidence measures.
View Article and Find Full Text PDFLittle is known about the genetic diversity of Salmonella enterica serovar Typhi (S. Typhi) circulating in Latin America. It has been observed that typhoid fever is still endemic in this part of the world; however, a lack of standardized blood culture surveillance across Latin American makes estimating the true disease burden problematic.
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- Antimicrobial resistance (AMR) is a significant threat to treating typhoid fever, with an outbreak of extensively drug-resistant Salmonella Typhi in Pakistan making azithromycin the last effective oral option in South Asia, though azithromycin-resistant strains have appeared in neighboring countries.
- A study in Northern India analyzed 66 S. Typhi isolates using whole-genome sequencing and found 7 strains with a specific mutation linked to azithromycin resistance, along with mutations conferring ciprofloxacin resistance in 6 of those strains.
- The emergence of these resistant strains emphasizes a growing AMR problem in South Asia and highlights the urgent need for introducing typhoid conjugate vaccines in the region.
Objectives: The diagnosis of typhoid fever is a challenge. Aiming to develop a typhoid diagnostic we measured antibody responses against Salmonella Typhi (S. Typhi) protein antigens and the Vi polysaccharide in a cohort of Bangladeshi febrile patients.
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