Publications by authors named "Thanawan Rattanakul"
J Clin Pharmacol
October 2024
Article Synopsis
- * The study aimed to optimize TDF dosing using population pharmacokinetic (PPK) models and Monte Carlo simulations to find effective regimens for patients with moderate and severe renal impairment.
- * Results indicated that smaller daily doses of TDF (150 mg for moderate and 75-100 mg for severe impairment) provided consistent drug exposure similar to standard doses without the variability associated with extended dosing intervals, suggesting a safer approach to minimize potential nephrotoxicity.
