Aims: Ethanol is known to induce NO release and coronary vasorelaxation. Evidence suggests that K channels, especially a Ca-activated K channel (K), may regulate endothelial NO production. We aimed to investigate the ethanol effect on K currents in human coronary artery endothelial cells (HCAECs), identify the K channel type/subtype and signaling pathway involved, and demonstrate the relevance to ethanol-induced NO release.
View Article and Find Full Text PDF