Cost-effectiveness of oral agents in relapsing-remitting multiple sclerosis compared to interferon-based therapy in Saudi Arabia.

Background: Promising clinical and humanistic outcomes are associated with the use of new oral agents in the treatment of relapsing-remitting multiple sclerosis (RRMS). This is the first cost-effectiveness study comparing these medications in Saudi Arabia.

Objectives: We aimed to compare the cost-effectiveness of fingolimod, teriflunomide, dimethyl fumarate, and interferon (IFN)-b1a products (Avonex and Rebif) as first-line therapies in the treatment of patients with RRMS from a Saudi payer perspective.

Functional neurosurgery. The modulation of neural and mind circuits.

Different complex neuroanatomical and neurochemical circuits regulate a variety of neuronal behaviors and brain functions. Any disturbance in these circuits can generate functional disorders such as movement disorders, epilepsy, pain, memory disorders, and psychiatric disorders. Functional neurosurgery aims to restore these functions, either by removing or isolating the abnormally behaving neurons or by modulating the disturbed circuits.

Natural course of epilepsy concomitant with CNS tuberculomas.

Background: Epilepsy is relatively common in CNS tuberculomas, but its natural course is unclear.

Aim: To determine the prevalence and prognosis of epilepsy in patients with seizures related to CNS tuberculomas.

Methods: We retrospectively reviewed the charts of patients with CNS tuberculomas who presented at our institution between 1983 and 2001.