Publications by authors named "Tham S"

Burnout is a prevalent phenomenon in medicine, affecting >50% of physicians and up to 60% of medical residents. This has negative consequences for both doctors' mental health and job satisfaction as well as patient care quality. While numerous studies have explored the causes, psychological effects, and workplace solutions, we aim to practicalize the issue from the perspectives of residents by discussing three key drivers of burnout and offering actionable, multipronged strategies that may be able to tackle these root causes effectively.

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Objective: To identify factors associated with dementia among older people in Malaysia.

Methods: This study used data from a nationwide cross-sectional survey in Malaysia. Participants involved were older people aged 60 years and above.

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Purpose: The scapholunate ligament (SLL) is the most frequently injured wrist ligament. The aim of this study was to investigate cellular and extracellular changes within the SLL following injury.

Methods: Fifteen SLLs were harvested, ranging between 39 days to 20 years from time of injury.

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Background: Traditional teaching advocates for routine patella resurfacing (PR) during total knee arthroplasty (TKA) in patients with inflammatory arthritis. However, evidence on this topic remains limited in the Asian population. This study aims to evaluate the postoperative outcomes and complication of patella resurfacing (PR) during primary total knee arthroplasty (TKA) in Asian patients with inflammatory arthritis.

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The current study explored whether social support received from either mediated or in-person contact varied among international students depending on the level of social ties (stronger/weaker) with existing support groups. This study also examined whether in-person or computer mediated social support (CMSS) is a better predictor of acculturative stress which might influence mental health of international students. An online survey was conducted among 179 international students across three U.

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  • Psoriasis is a chronic inflammatory skin disease that requires varied management approaches, which the study aimed to standardize through new guidelines tailored for dermatology practice in Singapore.
  • A specialized workgroup conducted a comprehensive literature review on psoriasis treatments from 2013 to 2023, refining clinical questions to create practical guidelines covering assessment and management strategies for different severity levels of psoriasis.
  • The resulting guidelines suggest various therapies, including both systemic and topical treatments, while addressing specific concerns for special populations and providing recommendations for managing related conditions like psoriatic arthritis.
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  • The study aimed to assess the long-term effects of trapeziectomy and ligament reconstruction with tendon interposition (LRTI) in patients under 56 years suffering from trapeziometacarpal osteoarthritis.
  • It involved a retrospective analysis of 105 patients, with 48 returning for follow-up assessments, measuring pain and hand function over a mean period of 11 years post-surgery.
  • Results indicated that while the procedures are generally effective, there is a deterioration in patient-reported outcomes and pain levels over time, suggesting the need to weigh the benefits against long-term effects.
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Introduction Adolescent pregnant mothers are at higher risk of acquiring anemia during pregnancy, which has detrimental consequences for the mother and baby. Untreated and prolonged anemia can lead to perinatal morbidity and mortality and antepartum, intrapartum, and postpartum maternal morbidity. Anemia among adolescent pregnant mothers can be attributed to many factors, such as poor nutrition and the physiological demands of pregnancy.

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The relationship between socioeconomic status (SES) and health outcomes has garnered significant attention. However, there is a limited amount of research exploring the association between SES and the risk of metabolic syndrome in Malaysian adults. This study aimed to determine the association between SES and risk of hypertension, diabetes and obesity.

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  • - The study investigates the experiences of adolescents with chronic pain who may show signs of medical child abuse (MCA), highlighting how the level of disability can exceed medical findings.
  • - Researchers analyzed medical records of 37 adolescents aged 13-18 from an academic children's hospital, categorizing themes into three levels of concern for MCA: 'Green zone' (common issues), 'Yellow zone' (more concerning factors), and 'Red zone' (directly linked to MCA).
  • - The findings identified commonalities in medical narratives and emphasized the need for careful assessment by healthcare providers to determine the potential risk of MCA in adolescents with chronic pain.
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Introduction: Platypnoea-orthodeoxia syndrome (POS) is an uncommon clinical entity characterised by dyspnoea and platypnoea (oxygen desaturation that follows the assumption of an upright position from recumbency). Since the coronavirus disease 2019 (COVID-19) outbreak, increasing reports of COVID-19-related POS and its associated morbidity have been reported around the world. We aimed to study the characteristics of COVID-19-related POS and orthodeoxia (including associations leading to a more prolonged orthodeoxia), and the postdischarge functional outcomes of patients with COVID-19-related POS.

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Background: As with many countries worldwide, Singapore is experiencing a rapidly ageing population. Presentation of older persons for urgent but non-emergent conditions to the Emergency Department (ED) represents a growing group of patients utilising public healthcare emergency services and puts a strain on current ED resources. The medical conditions vary, and resources used has been poorly characterized.

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The aim of this study was to evaluate the chicken femur as a laboratory model for the human metacarpal by comparing the bone microarchitecture and mechanical properties of chicken femurs to human cadaveric metacarpals. Sixteen fresh chicken femora and 20 fresh frozen cadaveric human metacarpals were imaged using a micro computed tomography scanner. The bones were then mechanically tested using four-point-bending and torsional testing.

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Glutathione-S-transferases (GST) enzymes detoxify xenobiotics and are implicated in response to anticancer therapy. This study evaluated the association of GST theta 1 (GSTT1), GSTT2, and GSTT2B with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) response in non-muscle-invasive bladder cancer treatment. In vitro assessments of GSTT2 knockout (KO) effects were performed using cell lines and dendritic cells (DCs) from GSTT2KO mice.

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  • This study investigates how the cancer treatment drug abiraterone affects the liver transport proteins OATP1B1 and OATP1B3, focusing on the use of coproporphyrin I (CP-I) as a biomarker to measure these effects.
  • The results showed that abiraterone inhibits the uptake of CP-I through OATP1B3 but not OATP1B1, with in vitro tests revealing a moderate inhibition constant and clinical simulations indicating no significant drug interaction.
  • Overall, the findings suggest that the risk of interaction between abiraterone and other drugs that rely on OATP1B transporters is low, meaning that OATP1B3 does
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  • Burnout and overwork are common issues for junior training physicians, leading to protests for better working conditions and a concerning number of professionals leaving the field.
  • Despite the implementation of duty hour restrictions in 2003 that limit residents to 80 hours a week, these measures have not effectively reduced burnout or improved working conditions over the last two decades.
  • The article argues for a dual approach that combines a meaningful reduction in working hours with improvements in the quality of both clinical and non-clinical work environments to better address resident burnout and enhance training outcomes.
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Scaffolds for bone defect treatment should ideally support vascularization and promote bone formation, to facilitate the translation into biomedical device applications. This study presents a novel approach utilizing 3D-printed water-dissolvable polyvinyl alcohol (PVA) sacrificial molds to engineer polymerized High Internal Phase Emulsion (polyHIPE) scaffolds with microchannels and distinct multiscale porosity. Two sacrificial mold variants (250 µm and 500 µm) were generated using fused deposition modeling, filled with HIPE, and subsequently dissolved to create polyHIPE scaffolds containing microchannels.

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Early extubation after pediatric cardiac surgery has come full circle from being practiced in the early days of pediatric cardiac surgery, falling out of favor with opioid-heavy cardiostable anesthesia, and resurfacing again in more recent times as part of enhanced recovery after surgery practice. Early extubation is variably defined, but is mostly accepted as extubation that occurs within 6-8 h from the end of surgery. In recent years, the debate has shifted from early extubation in the intensive care unit to immediate extubation in the operating theatre.

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  • The study compares two surgical methods (costal-osteochondral graft (COG) and medial femoral trochlea (MFT) graft) for treating fragmented fractures of the scaphoid with over two years of follow-up.
  • Both methods showed similar outcomes in terms of pain and wrist function, but there was a distinct radiographic finding where COG patients had evidence of arthritis, while MFT patients did not.
  • MFT patients experienced knee pain as a complication, while COG patients faced the risk of developing wrist arthritis over time.
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 In recent years, the classification and treatment algorithm for adult Kienböck's disease (KD) has expanded. However, the priority of the investigations done in determining its management has not been discussed, as not every patient with KD requires magnetic resonance imaging (MRI) or wrist arthroscopy.  We discuss the role of these investigations and emphasize the importance of computed tomography (CT) imaging in evaluating the cortical integrity of the lunate and its role in the decision-making process and management of KD.

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Objective: The authors investigated barriers to practices that promote family involvement in mental health services, focusing on individuals with severe mental illness, their families, and mental health providers. Additionally, the authors sought to identify strategies to facilitate family involvement in mental health provision to highlight the engagement process in routine practice and propose future directions for organizations to establish a family-friendly environment.

Methods: Systematic searches for literature published from January 1990 to March 2023 were conducted in PsycInfo, PubMed, CINAHL, Sociological Abstracts, and Scopus databases.

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  • Major changes in sleep patterns during adolescence include a shift to later sleep and wake times, which may affect pain experiences in this age group.
  • A study analyzed data from nearly 6,000 adolescents to explore how their sleep preferences (chronotype) influenced the onset of pain over a year.
  • Results showed that those with later chronotypes had a significantly higher likelihood of developing pain, including moderate-to-severe and multiregion pain, suggesting a connection between sleep patterns and pain incidence.
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