Garcicowanones C-E, three new hydrated-geranylated xanthones from the roots of Roxb. ex Choisy, and their -glucosidase inhibition activities.

Three new xanthones, garcicowanones C-E (), and six known xanthones () were isolated from the roots of Roxb. ex Choisy. Their chemical structures were determined using spectroscopic technics, including HR-ESI-MS and 2 D NMR.

New sesquiterpene and flavone arabinofuranoside derivative from the leaves of .

A new muurolane-type sesquiterpene, a new flavone arabinofuranoside derivative, and other five known flavone arabinofuranoside derivatives were isolated from the leaves of (Annonaceae family). Their chemical structures were determined to be (1,6,7)-muurola-4,10(14)-diene-15-ol (), quercetin 3---D-apiofuranosyl-(1→2)--L-arabinofuranoside (), quercetin 3---L-rhamnopyranosyl-(1→2)--L-arabinofuranoside (), quercetin 3---L-arabinofuranoside (), kaempferol 3---D-apiofuranosyl-(1→2)--L-arabinofuranoside (), kaempferol 3---L-rhamnopyranosyl-(1→2)--L-arabinofuranoside (), and kaempferol 3---L-arabinofuranoside () by analyses of HR-ESI-MS and NMR spectral data. Compounds and containing monosaccharide, arabinofuranoside, potentially inhibited NO productions in LPS activated RAW264.

Wedtrilosides A and B, two new diterpenoid glycosides from the leaves of Wedelia trilobata (L.) Hitchc. with α-amylase and α-glucosidase inhibitory activities.

In the ongoing research to find new diabetes constituents from the genus Wedelia, the chemical constituent of Wedelia trilobata leaves, a Vietnamese medicinal plant species used to treat type 2 diabetes mellitus, was selected for detailed investigation. From a methanolic extract, two new ent-kaurane diterpenoids, wedtrilosides A and B (1 and 2), along with five known metabolites (3-7), were isolated from W. trilobata.

Synthesis and cytotoxic evaluation of novel indenoisoquinoline-substituted triazole hybrids.

The synthesis of various substituted triazole-indenoisoquinoline hybrids was performed based on a CuI-catalyzed 1,3-cycloaddition between propargyl-substituted derivatives and the azide-containing indenoisoquinoline. Besides, a variety of N-(alkyl)propargylindenoisoquinolines was used as substrates for the construction of triazole-indenoisoquinoline-AZT conjugated via a click chemistry-mediated coupling with 3'-azido-3'-deoxythymidine (AZT). Thus, twenty three new indenoisoquinoline-substituted triazole hybrids were successfully prepared and evaluated as cytotoxic agents, revealing an interesting anticancer activity of four triazole linker-indenoisoquinoline-AZT hybrids in KB and HepG2 cancer cell lines.

Synthesis of new simplified hemiasterlin derivatives with α,β-unsaturated carbonyl moiety.

In this Letter, we report a convenient and efficient method for the synthesis of new simplified derivatives of hemiasterlin in which the α,α-dimethylbenzylic moiety A is replaced by α,β-unsaturated aryl groups as Michael acceptor. Most of these derivatives have a strong cytotoxic activity on three human tumor cell lines (KB, Hep-G2 and MCF7). Analogs 17b and 17f showed a high cytotoxicity against KB and Hep-G2 cancer cell lines comparable to paclitaxel and ellipticine.