Publications by authors named "Thalita de Freitas Souza"
Insights into the bioactive potential of the Amazonian species Acmella oleracea leaves extract: A focus on wound healing applications.
Júlia Bertolini Fajardo Mariana Hauck Vianna Ana Barbara Polo Mariane Rocha Cordeiro Comitre Débora Almeida de Oliveira Thalita de Freitas Souza
J Ethnopharmacol
January 2025
Article Synopsis
- Acmella oleracea, traditionally used in Amazonian medicine for various ailments, contains bioactive compounds that could have therapeutic potentials, but scientific research on its wound healing properties is limited.
- The study aimed to analyze the phytochemical composition of methanolic extracts of A. oleracea leaves and to evaluate their antioxidant, anti-inflammatory, antimicrobial, and wound healing activities.
- Results showed the presence of key compounds like vanillic acid and quercetin in the extract, which exhibited strong anti-inflammatory effects and cytocompatibility without inducing toxicity in tested cells, highlighting its potential for wound healing applications.
Drug repositioning has been an important ally in the search for new antifungal drugs. Statins are drugs that act to prevent sterol synthesis in both humans and fungi and for this reason they are promissory candidates to be repositioned to treat mycoses. In this study we evaluated the antifungal activity of atorvastatin by in vitro tests to determine the minimum inhibitory concentration against azole resistant Candida albicans and its mechanisms of action.
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