Publications by authors named "Thalita Mayumi Castaldelli Nishime"
Article Synopsis
- - This study investigated how low-temperature plasma jet using helium (LTP-helium) affects cariogenic biofilms made of different bacterial combinations, testing the treatment for various time durations (1, 3, 5, and 7 minutes)! - The effectiveness of LTP-helium was compared to a 0.12% chlorhexidine solution (positive control) and sterile physiologic solution (negative control), with significant reductions in biofilm viability observed with LTP-helium (p < 0.0001)! - Results showed LTP-helium significantly decreased the viability of multispecies biofilms, suggesting it could be a promising method for preventing and treating dental caries!
(1) Background: Previous studies reported the promising inhibitory effect of cold atmospheric plasma (CAP) on . However, the exact mechanisms of CAP's action on the fungal cell are still poorly understood. This study aims to elucidate the CAP effect on cell wall, by evaluating the alterations on its structure and biochemical composition; (2) Methods: cells treated with Helium-CAP were analyzed by atomic force microscopy (AFM) and Fourier transform infrared spectroscopy (FTIR) in order to detect morphological, topographic and biochemical changes in the fungal cell wall.
View Article and Find Full Text PDFThe increasing incidence of antifungal resistance represents a great challenge in the medical area and, for this reason, new therapeutic alternatives for the treatment of fungal infections are urgently required. Cold atmospheric plasma (CAP) has been proposed as a promising alternative technique for the treatment of superficial candidiasis, with inhibitory effect both in vitro and in vivo. However, little is known on the association of CAP with conventional antifungals.
View Article and Find Full Text PDFDue to the limitations of traditional periodontal therapies, and reported cold atmospheric plasma anti-inflammatory/antimicrobial activities, plasma could be an adjuvant therapy to periodontitis. was grown in blood agar. Standardized suspensions were plated on blood agar and plasma-treated for planktonic growth.
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- - The study investigated how cold atmospheric pressure plasma (CAPP) jet affects the growth, germination, and adherence of the fungus Trichophyton rubrum, which causes nail infections.
- - Laboratory tests showed that exposing T. rubrum to plasma jet for 10 and 15 minutes completely stopped its mycelial growth and significantly reduced its ability to germinate and infect nail samples.
- - Biochemical analysis confirmed these findings, indicating that a single 15-minute exposure to CAPP is a potentially effective treatment for fungal nail infections caused by T. rubrum.
The aim of this study was to establish an effective and safe protocol for in vivo oral candidiasis treatment with atmospheric plasma jets. A novel amplitude-modulated cold atmospheric pressure plasma jet (AM-CAPPJ) device, operating with Helium, was tested. In vitro assays with Candida albicans biofilms and Vero cells were performed in order to determine the effective parameters with low cytotoxicity.
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