Publications by authors named "Thalia Jang"
Article Synopsis
- A series of novel ferrocene-functionalized Ru(III) complexes were synthesized by modifying the anti-metastatic compound NAMI-A through direct coupling with ferrocene at various positions on pyridine, affecting their stability and bioavailability.
- Studies using electron paramagnetic resonance (EPR) and UV-vis spectroscopy showed that special configurations, particularly those substituting ferrocene at the 3 position, displayed improved solution stability and interactions with human serum albumin, hinting at enhanced biological properties.
- Cyclic voltammetry results indicated that while the ferrocene groups modestly alter the reduction potential of the Ru center, they also led to notable variations in the electrochemical behavior of the complexes, implying
A series of pyridine-based derivatives of the clinically successful Ru(III)-based complexes indazolium [trans-RuCl4(1H-indazole)2] (KP1019) and sodium [trans-RuCl4(1H-indazole)2] (KP1339) have been synthesized to probe the effect of hydrophobic interactions with human serum albumin (hsA) on anticancer activity. The solution behavior and protein interactions of the new compounds were characterized by using electron paramagnetic resonance (EPR) and UV/Vis spectroscopy. These studies have revealed that incorporation of hydrophobic substituents at the 4'-position of the axial pyridine ligand stabilizes non-coordinate interactions with hsA.
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