Synopsis of recent research by authors named "Thalia E Chan"
- Thalia E Chan's research focuses on unraveling the complexities of gene expression and regulatory networks at the single-cell level, particularly in the context of cancer and stem cell differentiation
- Her studies highlight the interplay between clonal genetic diversity and transcriptional plasticity in luminal breast cancers undergoing endocrine therapy, underscoring the limitations of traditional clonal selection models
- Chan has developed innovative computational tools and methodologies, such as the PIDC algorithm, to infer gene regulatory networks, enhancing our understanding of cell fate decisions and differentiation processes based on single-cell transcriptomic data
