Publications by authors named "Thais Moura"
Article Synopsis
- ISG15 deficiency is a rare inherited syndrome that leads to frequent infections by less harmful mycobacteria and interferon-related issues, and this study focuses on two unrelated Brazilian patients sharing the same genetic mutation in the ISG15 gene.
- Assessments revealed both patients had low production of IFN-γ and distinct clinical symptoms, impacting their immune response and leading to both infectious and neurological manifestations.
- The researchers identified a specific mutation (c.83 T > A) that destabilizes the ISG15 protein, along with a significant number of differentially expressed genes linked to immune pathways, marking the first documentation of these cases in Brazil.
Article Synopsis
- Snakebite envenoming is a major global public health issue, especially in Brazil, where Bothrops snakes cause most incidents, leading to complications and fatalities.
- A study from 2015-2021 analyzed data from various Brazilian municipalities to discover factors influencing snakebite incidence, utilizing Species Distribution Models and examining variables like precipitation, temperatures, and land use.
- Results showed that higher snakebite rates were primarily in northern Brazil, with increased incidents linked to extensive forests, historical forest loss, higher temperatures, and precipitation, suggesting a correlation with snake activity and human interactions.
Article Synopsis
- - Preeclampsia (PE) affects 3-5% of pregnancies globally and can lead to severe health issues for both mothers and babies, including eclampsia, placental abruption, and stroke.
- - The condition is linked to diseases of the endothelial system and involves complex interactions of genetic, acquired, and immunological factors that disrupt normal placentation and blood flow.
- - Recent research highlights the role of ion transporters in uterine circulation during placentation, suggesting that their dysregulation due to adverse conditions can contribute significantly to the development of preeclampsia.
Inflammatory turmoil within: an exploration of autoinflammatory disease genetic underpinnings, clinical presentations, and therapeutic approaches.
Adv Rheumatol
August 2024
Article Synopsis
- - Systemic autoinflammatory diseases (SAIDs) result from an overactive innate immune system, leading to widespread inflammation and are caused by various genetic defects that complicate diagnosis.
- - Despite advancements in genetic testing, around 40% of SAIDs patients still do not have a clear genetic diagnosis, and the disorders are grouped based on their unique pathophysiological features including inflammasomopathies and relopathies.
- - Targeted treatments are crucial, utilizing agents like JAK inhibitors and IL-1 blockers, to manage the distinct clinical presentations and inflammation associated with these complex diseases.
Objective: To identify areas that present a higher risk of exposure to accidents with scorpions in Brazil.
Methods: We used techniques of spatial prioritisation to determine the most vulnerable localities to envenomation by four scorpion species. Our prioritisation integrated ecological niche models with health investment, antivenin availability, access to health care facilities and metrics of human impact data.
Introduction: There is evidence that all the complex machinery involved in speech acts along with the auditory system, and their adjustments can be altered.
Objective: To present the evidence of biofeedback application for treatment of vocal disorders, emphasizing the muscle tension dysphonia.
Methods: A systematic review was conducted in Scielo, Lilacs, PubMed and Web of Sciences databases, using the combination of descriptors, and admitting as inclusion criteria: articles published in journals with editorial committee, reporting cases or experimental or quasi-experimental research on the use of biofeedback in real time as additional source of treatment monitoring of muscle tension dysphonia or for vocal training.