Kinin B Receptor Acts in Adipose Tissue to Control Fat Distribution in a Cell-Nonautonomous Manner.

The kinin B receptor (BR) plays a role in inflammatory and metabolic processes. BR deletion (B ) protects mice from diet-induced obesity and improves insulin and leptin sensitivity. In contrast, genetic reconstitution of BR exclusively in adipose tissue reverses the lean phenotype of B mice.

Increased bone loss and amount of osteoclasts in kinin B1 receptor knockout mice.

Aim: The pathophysiology of periodontal diseases involves aspects of immunity and bone remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and healing, the purpose of this study was to evaluate the contribution of Bdkrb1 to the pathogenesis of periodontitis.

Material And Methods: We used a model of ligature-induced experimental periodontitis (LIEP) in mice lacking Bdkrb1 (Bdkrb1(-/-) ) to test the role of this receptor in bone loss and cytokine secretion by lymph nodes cells.