Publications by authors named "Thais Fischer"
Introduction: The diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma (NHL) and, despite all the progress in this field, central nervous system infiltration (CNSi) still occurs at an incidence of 2-10%. The objective of the present study was to evaluate the Central Nervous System International Prognostic Index (CNS-IPI) score in daily practice regarding the reproducibility in a heterogeneous cohort apart from a clinical trial.
Methods: Primary DLBCL patients were eligible for this study, between January 2007 and January 2017.
Sterile bracts can represent 80% of pinecone and are a rich source of phenolic compounds. This study aimed to optimize the extraction of the phenolic compounds from bracts using response surface methodology; the bioactivity properties were also investigated. The effects of the ethanol concentration, solute/solvent ratio, and temperature in relation to the phenolic composition and antioxidant activity were evaluated.
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- The T-cell Lymphoma Project is a global study that examined clinical features and treatment outcomes of patients with newly diagnosed peripheral T-cell and NK-cell lymphomas, enrolling 1553 patients from 74 institutions across 14 countries between 2006 and 2018.
- Among the participants, 131 (8.4%) were identified with anaplastic large cell lymphoma - kinase positive (ALCL, ALK+), mostly in young adults with a median age of 39; many patients had advanced-stage disease but a majority had low-risk scores.
- Treatment with anthracycline chemotherapy yielded an 81% overall response rate, with 70% achieving complete remission, and three- and five-year overall survival rates
The apple pomace-industrial residue of apple beverages manufacture-presents 42-58% of the phenolic content of fresh fruit. As the phenolic composition influences the quality of ciders, it is very relevant to monitor the evolution of these compounds during the industrial process. Therefore, this research aim was to monitor the cider composition with the addition of phenolic extract from apple pomace during the fermentation.
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- Treatment with anti-CD20 monoclonal antibodies improves outcomes in B-cell malignancies but increases the risk of hypogammaglobulinemia (HG).
- In a study of 380 follicular lymphoma patients, increased exposure to anti-CD20 mAb led to significant differences in serum immunoglobulin levels and the prevalence of HG.
- The findings suggest that monitoring serum immunoglobulins is important for all follicular lymphoma patients, even those not receiving active treatment, as tumor burden may also influence Ig levels.
Non-Hodgkin lymphomas with T-cell immunophenotype encompass a heterogeneous group of infrequent neoplasms that follow variable clinical courses but prevalently include aggressive behavior and high mortality rates. The involvement of the central nervous system (CNS) is an uncommon event in T-cell lymphomas, with wide variability among the different disease entities. CNS can be affected either at initial diagnosis or at recurrence, and both forms are considered "secondary CNS T-cell lymphoma".
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- - The study compares the outcomes of immediate therapy versus observation in patients with advanced follicular lymphoma (FL), highlighting that overall survival (OS) benefits are hard to show but time to second treatment (TT2T) might be a better measure.
- - Among 584 patients analyzed, those who were initially observed (248 patients) experienced a median time to first treatment of 3.3 years and a TT2T of 12.1 years, with 82% surviving after 10 years.
- - TT2T shows a strong correlation with OS for both observed and treated patients, suggesting it could serve as a useful indicator of survival, especially in identifying high-risk patients for early intervention trials.
Article Synopsis
- The COVID-19 outbreak is classified as a global pandemic, impacting over 1.3 million individuals globally.
- Cancer patients, especially those with lymphoid malignancies, face increased risks of severe illness, including ICU admission and higher mortality rates.
- The article discusses strategies for managing patients with lymphoid malignancies during the pandemic, emphasizing the importance of minimizing their risk during treatments that often require frequent medical visits.
The World Health Organization classification for peripheral T-cell lymphomas (PTCLs) continues to evolve based on genetic and clinical distinctions of each entity. In Part 1, an overview was provided of PTCL not otherwise specified, follicular T-cell lymphoma, angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), and breast implant-associated ALCL. In Part 2, this review is extended to extranodal natural killer (NK)/T-cell lymphoma, enteropathy-associated T-cell lymphoma, indolent T-cell lymphoproliferative disorder of the gastrointestinal tract, adult T-cell leukemia/lymphoma, and hepatosplenic T-cell lymphoma.
View Article and Find Full Text PDFPeripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of diseases, with low incidence and unique epidemiology and pathobiology; they are usually clinically aggressive, with poor outcomes. There have been significant advances in our understanding of the molecular and signaling alterations seen in these malignancies. These observations have led to novel therapeutic strategies that have had a meaningful impact on outcomes.
View Article and Find Full Text PDFFollicular Lymphoma (FL) is the second most common type of non-Hodgkin lymphoma and is considered to be the prototype of indolent lymphomas. Histologic transformation into an aggressive lymphoma, which is expected to occur at a rate of 2 to 3% each year, is associated with rapid progression, treatment resistance, and poor prognosis. Recent modifications to the physiopathologic mechanism of transformed follicular lymphoma (t-FL) have been proposed, including genetic and epigenetic mechanisms as well as a role for the microenvironment.
View Article and Find Full Text PDFBackground: Despite all the scientific progress that has been made on understanding the disease, prognosis for patients with relapsed and refractory Hodgkin's lymphoma remains poor and the treatment is palliative in the majority of the cases. Thus, the aim of this study was to present the results on the compassionate use of everolimus in a group of patients who were monitored at nine different centers in Brazil.
Methods: A 10-mg oral dose of everolimus was given to each patient daily.