Effect of fixed 7.5 minutes' moderate intensity exercise bouts on body composition and blood pressure among sedentary adults with prehypertension in Western-Kenya.

Prehypertension is a modifiable risk factor for cardiovascular disease observed to affect an estimated 25-59% of global population and closely associated with body composition. Without appropriate interventions, one-third of individuals with prehypertension would develop full-blown hypertension within 4 years. The existing exercise recommendations need substitutes that appeal more yet accord similar or better outcomes in desire to halt this progression.

Effect of short moderate intensity exercise bouts on cardiovascular function and maximal oxygen consumption in sedentary older adults.

Aim: To investigate effect of <10 min moderate intensity exercise on cardiovascular function and maximal oxygen consumption ( Omax) among sedentary adults.

Methods: We studied 53 sedentary urbanites aged ≥50 years, randomised into: (1) male (M) and (2) female (F) undertaking three short-duration exercise (5-10 min) daily, and (3) male (M) and (4) female (F) exercising 30-60 min 3-5 days weekly. Resting systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate and Omax were measured at baseline and 8 weekly for 24 weeks.

Effect of moderate-intensity exercise bouts lasting <10 minutes on body composition in sedentary Kenyan adults aged ≥50 years.

Background: Sedentary lifestyles and related morbidities are rising among adults despite existing exercise recommendations. Appealing exercise regimes yielding similar/better body composition should be sought.

Objective: We investigated the effect of moderate-intensity exercise bouts of <10 min on body composition in previously sedentary adults.

Effect of short and long moderate-intensity exercises in modifying cardiometabolic markers in sedentary Kenyans aged 50 years and above.

Objectives: We compared effects of shorter moderate-intensity exercise time (<10 min bouts) on cardiometabolic parameters with the current recommendations among elderly adults.

Methods: Fifty-three sedentary individuals aged ≥50 years were divided into exercise groups1: male and2 female short-duration bouts (M and F, respectively), and3 male and4 female long-duration bouts (M and F, respectively). Short-duration bouts consisted three 5-10 min moderate-intensity jogging sessions daily, and long-duration bouts consisted 30-60 min sessions 3-5 days weekly.

Identification and estimation of a cholinomimetic substance in the venom of Dendroaspis polylepis.

A cholinomimetic substance was isolated from desiccated venom of Dendroaspis polylepis by one-dimensional ascending paper chromatography. The migratory and staining properties of the substance were compared with those of standard acetylcholine. Pharmacological and biochemical identification was carried out on various in vitro and in vivo biological test objects as well as with high-voltage paper electrophoresis.

Identification and isolation of three acetylcholinesterase inactivating fractions in the venom of Dendroaspis angusticeps.

Three fractions were isolated from the venom of Dendroaspis angusticeps by column chromatography on CM-Sephadex C-25. All the three fractions were shown to possess acetylcholinesterase inhibiting activity. The toxicity of the fractions as tested on mice were variable.

Skeletal neuromuscular and smooth muscle effects of whole venom of the green mamba, Dendroaspis angusticeps - I.

Dendroaspis angusticeps venom (75 micrograms/ml) caused an irreversible blockade of the directly as well as directly evoked contractions of the rat hemidiaphragm and indirectly evoked contractions of the chick biventer cervicis muscle. The venom itself also produced a contraction of the frog rectus abdominis muscle, rat fundal strip, rat uterus and nictitating membrane of the cat; however, it did alter responses of nictitating membrane to preganglionic electrical stimulation and to ganglion stimulant drugs. The effect was attributed to the presence of acetylcholine-like substance in the venom.

Myocardial depressant fraction in the venom of Dendroaspis angusticeps.

Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine.