Publications by authors named "Thai Hoa Thi Nguyen"
Liquid biopsy uncovers distinct patterns of DNA methylation and copy number changes in NSCLC patients with different EGFR-TKI resistant mutations.
Hoai-Nghia Nguyen Ngoc-Phuong Thi Cao Thien-Chi Van Nguyen Khang Nguyen Duy Le Dat Thanh Nguyen Quynh-Tho Thi Nguyen Thai-Hoa Thi Nguyen Chu Van Nguyen Mai-Lan Thi Nguyen Trieu Vu Nguyen Luan Thanh Nguyen Sinh Duy Nguyen
Sci Rep
August 2021
Article Synopsis
- Targeted therapy using tyrosine kinase inhibitors (TKI) can improve survival rates for many patients with non-small cell lung cancer (NSCLC), but resistance to these treatments often develops.
- A study analyzed the genetic and epigenetic changes in 122 Vietnamese NSCLC patients experiencing resistance to TKI therapy, finding that 41.8% had specific resistance mutations, particularly in the EGFR gene.
- The research highlighted that the level of genome-wide hypomethylation was linked to how long patients responded to TKI, suggesting that liquid biopsies can help understand TKI resistance mechanisms and inform future treatment strategies.
Lung cancer has been the leading cause of cancer-related deaths in both developed and developing countries, with most primary lung cancers being non-small cell lung carcinomas. Treatment for this condition is sometimes individualized. With developments in modern treatment and phase III clinical trial results, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) and ALK-TKI have proven thier superior effectivity in comparison with the standard platinum-based doublet and are commonly approved as first-line indications in previously untreated advanced non-small cell lung cancer (NSCLC) patients with EGFR or ALK mutations.
View Article and Find Full Text PDFUltra-Deep Massive Parallel Sequencing of Plasma Cell-Free DNA Enables Large-Scale Profiling of Driver Mutations in Vietnamese Patients With Advanced Non-Small Cell Lung Cancer.
Le Son Tran Quynh-Tho Thi Nguyen Chu Van Nguyen Vu-Uyen Tran Thai-Hoa Thi Nguyen Mai-Lan Thi Nguyen Luan Thanh Nguyen Thien-Chi Van Nguyen Long Hung Nguyen Thanh-Thanh Thi Nguyen Kim-Huong Thi Nguyen Nguyen Huu Nguyen Hoai-Nghia Nguyen
Front Oncol
August 2020
Article Synopsis
- Population-specific profiling of cancer gene mutations is essential for better understanding cancer biology and improving diagnostics and treatment tailored to specific groups.
- The study used ultra-deep massive parallel sequencing of plasma cell-free DNA (cfDNA) to analyze mutations in 265 Vietnamese patients with advanced non-small cell lung cancer, offering a less invasive alternative to traditional tumor tissue analysis.
- Although cfDNA testing had lower mutation detection rates, it still identified major mutations in key driver genes that were consistent with findings from tissue sample analysis, highlighting its potential for large-scale genetic profiling in populations with limited access to tumor biopsies.
Actionable Mutation Profiles of Non-Small Cell Lung Cancer patients from Vietnamese population.
Anh-Thu Huynh Dang Vu-Uyen Tran Thanh-Truong Tran Hong-Anh Thi Pham Dinh-Thong Le Lam Nguyen Ngoc-Vu Nguyen Thai-Hoa Thi Nguyen Chu Van Nguyen Mai-Lan Thi Nguyen Phuc Huu Nguyen Luan Thanh Nguyen Thien-Chi Van Nguyen Quynh-Tram Nguyen Bui Long Hung Nguyen Nguyen Huu Nguyen Quynh-Tho Thi Nguyen Hoai-Nghia Nguyen
Sci Rep
February 2020
Article Synopsis
- - Comprehensive profiling of mutations in non-small cell lung cancer (NSCLC) is crucial for guiding targeted therapies and improving patient survival, especially in high-incidence regions like Vietnam.
- - A study involving 350 Vietnamese NSCLC patients identified that mutations in the EGFR gene (35.4%) and KRAS gene (22.6%) were the most common, with notable differences compared to other ethnic cohorts.
- - The research found that KRAS mutations were more prevalent in males, while EGFR mutations were more frequent in females, and younger patients (<61 years) showed higher rates of ALK and ROS1 rearrangements.