Hemolysin test as a tool to screen high-titer Group O platelet apheresis donors: A prospective study.

Background: Minor ABO-incompatible apheresis platelet transfusion poses a risk of hemolytic transfusion reactions in non-Group O recipients when donor's plasma possesses unusual high titers for anti-A and anti-B. The aim was to determine whether the hemolysin test can be used as a screening tool to predict high-titer Group O platelet apheresis donors.

Methods: A prospective study, with Group O platelet donor's samples, was tested for hemolysin test and antibody titration test in parallel.