Publications by authors named "Thadshagine Ganeswaran"
Article Synopsis
- During cell division, kinetochores, crucial for attaching chromosomes to spindle microtubules, typically form at centromeres with CENP-A nucleosomes, while the outer kinetochore structure is built by the KMN network that recruits downstream components.
- In C. elegans oocytes, while CENP-C is essential for kinetochore formation, it functions alongside nucleoporin MEL-28, suggesting a unique pathway that operates in parallel to the conventional CENP-A pathway.
- Research showed that both CENP-A/CENP-C and KNL-2/MEL-28 pathways are necessary for the assembly of kinetochores during meiosis I, with KNL-2 specifically
During cell division, chromosome congression to the spindle center, their orientation along the spindle long axis and alignment at the metaphase plate depend on interactions between spindle microtubules and kinetochores, and are pre-requisite for chromosome bi-orientation and accurate segregation. How these successive phases are controlled during oocyte meiosis remains elusive. Here we provide 4D live imaging during the first meiotic division in C.
View Article and Find Full Text PDFDuring cell division, chromosome segregation is orchestrated by a microtubule-based spindle. Interaction between spindle microtubules and kinetochores is central to the bi-orientation of chromosomes. Initially dynamic to allow spindle assembly and kinetochore attachments, which is essential for chromosome alignment, microtubules are eventually stabilized for efficient segregation of sister chromatids and homologous chromosomes during mitosis and meiosis I, respectively.
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