Publications by authors named "Thabo Mohale"

can breed in a range of saltwater concentrations. The consequences of this ability on the life history of adult are poorly understood. This study examined the effects of exposure to 0, 2.

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The coding-complete genome sequences of monkeypox virus (MPXV) were obtained from skin lesion swabs from two human cases detected in South Africa in June 2022. Sequence analyses indicated that the genetic sequences of the viruses associated with these two cases were related most closely to the genetic sequences of other MPXVs reported during the 2022 multicountry outbreak and belong to the monkeypox hMPXV-1 clade (previously West Africa clade) and B.1 lineage.

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Article Synopsis
  • A lot of money has been spent on studying the COVID-19 virus in Africa, leading to over 100,000 virus samples being analyzed to understand the spread of the disease.
  • *More countries in Africa are now able to do these studies themselves, which helps them get results faster and keep a close watch on the virus.
  • *To keep fighting COVID and other diseases, more funding and support for testing and research in Africa is really important for the future.
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The circulation of Omicron BA.1 led to the rapid increase in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases in South Africa in November 2021, which warranted the use of more rapid detection methods. We, therefore, assessed the ability to detect Omicron BA.

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Article Synopsis
  • Global genomic surveillance has found a new SARS-CoV-2 variant, C.1.2, in South Africa and eleven other countries, which shows increased transmissibility and potentially greater disease severity.
  • C.1.2 has a high substitution rate in its spike protein, related to reduced neutralization sensitivity, making it harder for antibodies from vaccinated individuals or those infected with earlier strains to effectively combat it.
  • Previous infections with variants Beta or Delta may provide some protection against C.1.2, suggesting that the vaccine's effectiveness against this new variant could be similar to that against the earlier concerning variants.
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The SARS-CoV-2 epidemic in southern Africa has been characterized by three distinct waves. The first was associated with a mix of SARS-CoV-2 lineages, while the second and third waves were driven by the Beta (B.1.

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Article Synopsis
  • The SARS-CoV-2 pandemic in Africa has varied significantly across countries, and its overall impact remains unclear.
  • An analysis of 8,746 genomes from 33 African countries indicated that most outbreaks originated from Europe before international travel restrictions took effect.
  • As the pandemic continued, increased movement and local transmission led to the emergence of several variants within Africa, emphasizing the need for a strong pandemic response on the continent to prevent becoming a source of new variants.
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Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.

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As a contribution to the global efforts to track and trace the ongoing coronavirus pandemic, here we present the sequence, phylogenetic analysis, and modeling of nonsynonymous mutations for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome that was detected in a South African patient with coronavirus disease 2019 (COVID-19).

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Most pneumococci express a polysaccharide capsule, a key virulence factor and target for pneumococcal vaccines. However, pneumococci showing no serological evidence of capsule expression [nontypeable pneumococci (NTPn)] are more frequently isolated from carriage studies than in invasive disease. Limited data exist about the population structure of carriage NTPn from the African continent.

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Background: More than 94 serotypes of Streptococcus pneumoniae have been described to date, however the majority of disease is caused by approximately 20 serotypes. Some pneumococci do not react with commercially available antisera used for serotyping and are thus regarded as non-serotypeable (NT). These pneumococci are commonly isolated during carriage studies and very rarely cause invasive disease.

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Background: The capsular polysaccharide is the principal virulence factor of Streptococcus pneumoniae and a target for current pneumococcal vaccines. However, some pathogenic pneumococci are serologically nontypeable [nontypeable pneumococci (NTPn)]. Due to their relative rarity, NTPn are poorly characterized, and, as such, limited data exist which describe these organisms.

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