Evaluation of Accuracy and Position of Milled and 3D-Printed Teeth in Digital Complete Dentures.

Purpose: To compare the accuracy of milled versus 3D-printed complete denture bases and teeth and to assess the position of the teeth in relation to the corresponding denture bases.

Materials And Methods: Two different manufacturing techniques were used in this study. In Group A, 10 complete dentures were digitally designed and fabricated by milling prepolymerized blocks of polymethyl methacrylate (PMMA).

Structure-activity relationships andz interindividual variability of drug responses: pharmacogenomics with antimicrobial drugs as a paradigm.

Adverse drug reactions represent a major health burden because they cause notable patient morbidity and mortality. From this viewpoint, several strategies have been developed to prevent or reduce adverse drug reactions. One such strategy is the use of pharmacogenomics.

A Comparison of Denture Base Retention and Adaptation Between CAD/CAM and Conventional Fabrication Techniques.

Purpose: To assess the retention and adaptation of milled and printed denture bases in comparison to conventional ones.

Materials And Methods: A total of 24 completely edentulous patients were selected. For each patient, three maxillary denture bases were constructed according to different fabrication techniques, thus defining the three groups for comparison: group 1 consisted of denture bases constructed by a conventional technique, group 2 consisted of denture bases milled from prepolymerized blocks of PMMA, and group 3 consisted of denture bases fabricated by a 3D printing technique.

Assessment of tooth positions of printed complete dentures with different designs and tooth positioning techniques.

Purpose: To evaluate the accuracy of tooth positions in printed complete dentures with different designs and teeth positioning techniques.

Materials And Methods: Five different designs of complete dentures and teeth positioning techniques were evaluated in this in vitro study. In Group I, the denture bases and teeth were designed as a single piece.

Customized scan bodies to facilitate intraoral scanning for full arch implant prosthesis: A dental technique.

This article presents the design of customized resin scan bodies with different forms and their use to facilitate intraoral scanning of a maxillary full arch implant case with five implants. The aim is to limit the distance between the scan bodies and to create definite landmarks to facilitate the scanning process in full arch implant cases.

Evaluation of the Accuracy and Adaptation of BioHPP Removable Partial Denture Frameworks Constructed by Milling vs the Pressing Technique.

Purpose: To evaluate the accuracy and adaptation of BioHPP removable partial denture frameworks constructed from milling vs the pressing technique.

Materials And Methods: This in vitro study was applied on an educational maxillary stone model with bilateral bounded saddles. Two different manufacturing techniques were used, and thus two groups were defined: (1) the pressed group, in which 20 BioHPP frameworks were constructed by milling a castable resin that was pressed into BioHPP using the lost wax technique; and (2) the milled group, in which 20 BioHPP frameworks were constructed directly by milling the BioHPP blanks.

Sulodexide Significantly Improves Endothelial Dysfunction and Alleviates Chest Pain and Palpitations in Patients With Long-COVID-19: Insights From TUN-EndCOV Study.

Objective: Non-respiratory long-coronavirus disease 2019 (COVID-19) symptoms are mainly related to a long-lasting endothelial dysfunction and microcirculation impairment. We hypothesized that Sulodexide, a purified glycosaminoglycan mixture with a beneficial endothelial effect in arterial and venous peripheral diseases, may be effective in a subset of patients with long COVID-19.

Approach And Results: We conducted a multicenter prospective quasi-experimental study.

Piezoionic mechanoreceptors: Force-induced current generation in hydrogels.

The human somatosensory network relies on ionic currents to sense, transmit, and process tactile information. We investigate hydrogels that similarly transduce pressure into ionic currents, forming a piezoionic skin. As in rapid- and slow-adapting mechanoreceptors, piezoionic currents can vary widely in duration, from milliseconds to hundreds of seconds.

Long COVID 19 Syndrome: Is It Related to Microcirculation and Endothelial Dysfunction? Insights From TUN-EndCOV Study.

The COVID-19 disease is a multisystem disease due in part to the vascular endothelium injury. Lasting effects and long-term sequelae could persist after the infection and may be due to persistent endothelial dysfunction. Our study focused on the evaluation of endothelial quality index (EQI) by finger thermal monitoring with E4 diagnosis Polymath in a large cohort of long COVID-19 patients to determine whether long-covid 19 symptoms are associated with endothelial dysfunction.

Subtractive versus additive indirect manufacturing techniques of digitally designed partial dentures.

Purpose: The purpose of this study was to evaluate the accuracy of digitally designed removable partial denture (RPD) frameworks, constructed by additive and subtractive methods castable resin patterns, using comparative 3D analysis.

Materials And Methods: A Kennedy class III mod. 1 educational maxillary model was used in this study.

Intratracheal Administration of Chloroquine-Loaded Niosomes Minimize Systemic Drug Exposure.

Pulmonary administration provides a useful alternative to oral and invasive routes of administration while enhancing and prolonging the accumulation of drugs into the lungs and reducing systemic drug exposure. In this study, chloroquine, as a model drug, was loaded into niosomes for potential pulmonary administration either via dry powder inhalation or intratracheally. Chloroquine-loaded niosomes have been prepared and extensively characterized.

Methods for preparation of niosomes: A focus on thin-film hydration method.

Development of nanocarriers has opened new avenues for the delivery of therapeutics of various pharmacological activities with improved targeting properties and reduced side effects. Niosomes, non-ionic-based vesicles, have drawn much interest in various biomedical applications, owing to their unique characteristics and their ability to encapsulate both hydrophilic and lipophilic cargoes. Niosomes share structural similarity with liposomes while overcoming limitations associated with stability, sterilization, and large-scale production of liposomes.

Retention of a telescopic overdenture on customized abutments after the simulation of 1 year in function.

Background: Telescopic implant-retained overdentures are considered one of the most common treatment modalities for edentulous patients.

Objectives: The aim of the study was to evaluate the retention of a BioHPP (biocompatible highperformance polymer) telescopic overdenture supported by customized abutments made from 2 different materials after the simulation of 1 year in function.

Material And Methods: Twelve models of a completely edentulous mandible were three-dimensionally (3D)-printed.

Publisher Correction: Tumor-necrosis factor impairs CD4 T cell-mediated immunological control in chronic viral infection.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

iRhom2 inhibits bile duct obstruction-induced liver fibrosis.

Chronic liver disease can induce prolonged activation of hepatic stellate cells, which may result in liver fibrosis. Inactive rhomboid protein 2 (iRhom2) is required for the maturation of A disintegrin and metalloprotease 17 (ADAM17, also called TACE), which is responsible for the cleavage of membrane-bound tumor necrosis factor-α (TNF-α) and its receptors (TNFRs). Here, using the murine bile duct ligation (BDL) model, we showed that the abundance of iRhom2 and activation of ADAM17 increased during liver fibrosis.

Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.

Regulatory T cells (Treg cells) are important for preventing autoimmunity and maintaining tissue homeostasis, but whether Treg cells can adopt tissue- or immune-context-specific suppressive mechanisms is unclear. Here, we found that the enzyme hydroxyprostaglandin dehydrogenase (HPGD), which catabolizes prostaglandin E (PGE) into the metabolite 15-keto PGE, was highly expressed in Treg cells, particularly those in visceral adipose tissue (VAT). Nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ)-induced HPGD expression in VAT Treg cells, and consequential Treg-cell-mediated generation of 15-keto PGE suppressed conventional T cell activation and proliferation.

Drug Formulations: Standards and Novel Strategies for Drug Administration in Pediatrics.

Child-appropriate drug formulations are a prerequisite of successful drug therapy in children. Efficacy and safety must be given for the active pharmaceutical ingredient, but safety also for the used excipients, components of primary packaging materials, and devices. We are presently experiencing exciting times for pediatric drug development, stimulated by previous governmental incentives in both the European Union and the United States.

Comparative study on disintegration methods for oral film preparations.

Orodispersible films (ODFs) provide high application comfort due to rapid disintegration in the oral cavity. They increasingly found the approval of pharmaceutical research and development and were added to the European Pharmacopeia in 2012. The European Pharmacopeia explicitly demands disintegration testing for ODFs, but does not refer to a suitable method.

Continuous inkjet printing of enalapril maleate onto orodispersible film formulations.

Piezoelectric inkjet printing onto orodispersible films (ODFs) was proven to be a successful technique applying flexible doses of active pharmaceutical ingredients (APIs) onto edible substrates. The reported API printing and ODF production was conducted in a non-continuous production approach. Within this study, drug-free and hydrochlorothiazide (HCT) containing ODFs should be imprinted in-line with enalapril maleate (EM) ink during continuous ODF production.

Continuous manufacturing and analytical characterization of fixed-dose, multilayer orodispersible films.

Various drug therapies require more than one active pharmaceutical ingredient (API) for an effective treatment. There are many advantages, e.g.

Flexible and precise dosing of enalapril maleate for all paediatric age groups utilizing orodispersible minitablets.

Enalapril is an off-patent angiotensin-converting enzyme inhibitor for which no paediatric age-appropriate formulation is commercially available in Europe, and enalapril maleate (EM) orodispersible minitablets (ODMTs) have previously been formulated within the LENA (labelling enalapril from neonates to adolescents) project. In this study, a dilution method has been developed by dispersing the lowest dose strength ODMTs to enable flexible and precise EM dosing during the dose titration phase of the therapy. Furthermore, the physicochemical stability of the ODMTs has been investigated in child-friendly beverages and the administration of ODMTs via nasogastric tubes (NGT) of different sizes and materials has been evaluated.

10 years EU regulation of pediatric medicines - impact on cardiovascular drug formulations.

Introduction: Child-appropriate drug formulations are mandatory for an efficient and safe drug therapy in children. Since the implementation of supportive legislations development of novel drug formulations has significantly been enforced despite the fact that children are a heterogeneous group of patients with varying needs according to age, maturation and disease.

Areas Covered: In this review, recent advances and current strategies are evaluated how to overcome the specific hurdles in pediatric drug development.

Orodispersible films: Product transfer from lab-scale to continuous manufacturing.

Orodispersible films have been described as new beneficial dosage forms for special patient populations. Due to various production settings, different requirements on film formulations are required for non- continuous and continuous manufacturing. In this study, a continuous coating machine was qualified in regards of the process conditions for film compositions and their effects on the formed films.

Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection.

Persistent viral infections are characterized by the simultaneous presence of chronic inflammation and T cell dysfunction. In prototypic models of chronicity--infection with human immunodeficiency virus (HIV) or lymphocytic choriomeningitis virus (LCMV)--we used transcriptome-based modeling to reveal that CD4(+) T cells were co-exposed not only to multiple inhibitory signals but also to tumor-necrosis factor (TNF). Blockade of TNF during chronic infection with LCMV abrogated the inhibitory gene-expression signature in CD4(+) T cells, including reduced expression of the inhibitory receptor PD-1, and reconstituted virus-specific immunity, which led to control of infection.