LED phototherapy in tissue repair of chronic wounds in people with diabetes: a systematic review.

Objective: To identify scientific evidence of LED photobiomodulation in the treatment and tissue repair of chronic wounds in people with Diabetes Mellitus, types I and II.

Method: Systematic review conducted from September/2021 to April/2022 in PubMed, LILACS, SCIELO, COHRANE, EMBASE and Web of Science. Randomized and observational clinical trials using LED in wound healing in diabetics, published between 2015 and 2022 were included.

Comparative study between 1-way and 2-way coupled fluid-structure interaction in numerical simulation of aortic arch aneurysms.

Hemodynamic forces are related to pathological variations of the cardiovascular system, and numerical simulations for fluid-structure interaction have been systematically used to analyze the behavior of blood flow and the arterial wall in aortic aneurysms. This paper proposes a comparative analysis of 1-way and 2-way coupled fluid-structure interaction for aortic arch aneurysm. The coupling models of fluid-structure interaction were conducted using 3D geometry of the thoracic aorta from computed tomography.

Hemostatic changes in patients undergoing hemodialysis: Differences between central venous catheters and arterio-venous fistulas.

Background: Failure to mature the fistula in patients undergoing hemodialysis leads to prolonged use of the central venous catheter (CVC) and can compromise the patency of the catheter and the arteriovenous fistula (AVF) due to thrombus development.

Objective: To evaluate hemostatic changes in patients undergoing hemodialysis with prolonged use of CVC or AVF.

Method: Cross-sectional study with a total of 200 adult participants who were divided into the following groups: I:control; II: patients who had 5-8 months of CVC insertion; III: patients who had 9-36 months of insertion; IV patients who had 5-8 months of AVF; and V: patients who had 9-36 months of AVF.

Microbiological and microstructural analysis of indwelling bladder catheters and urinary tract infection prevention.

Objective: To analyze the microbiological and microstructural part of indwelling urinary catheters and their association with urinary tract infection prevention.

Method: This is a cross-sectional study, from June to December 2020, in which 42 indwelling urinary catheter tips and sterile urine samples were collected for analysis of crystals in optical microscopy and biofilms in scanning electron microscopy. Culture analysis and specification of the type of bacteria were performed.

Detection of SARS-CoV-2 genome on inanimate surfaces in COVID-19 intensive care units and emergency care cohort.

Introduction: Understanding the different transmission routes of SARS-CoV-2 is crucial in planning effective interventions in healthcare institutions. This study aimed to evaluate the presence of SARS-Cov-2 genome on inanimate surfaces in COVID-19 intensive care unit and emergency care cohorts.

Methods: This is a prospective cross-sectional study.

Phototherapy (cluster multi-diode 630 nm and 940 nm) on the healing of pressure injury: A pilot study.

The therapeutic benefits of LED in wound care have been reported since the 1990s. Nevertheless, studies directly related to the effects of LED phototherapy on the venous and arterial circulation and the healing process of pressure injuries are scarce in literature. Thus, the aim of this study was to evaluate the efficacy of a LED phototherapy prototype in participants with pressure injuries.

Is it possible to decontaminate N95 masks in pandemic times? integrative literature review.

Objective: To evaluate the protocols on decontamination/reuse of N95 masks available in the literature in times of the Covid-19 pandemic.

Method: Integrative literature review, in the period from 2010 to 2020, on the databases MEDLINE/PubMed, Science Direct, Cochrane, SAGE journals, Web of Science, Scopus, Embase and Wiley, with the descriptors Masks AND Respiratory protective devices; Mask OR N95 AND Covid-19; N95 AND Respirators; Decontamination AND N95 AND Coronavirus; Facemask OR Pandemic.

Results: Twelve studies were included, of which 3 (30.

Influence of hemodialysis blood flow rate on the thrombogenic potential in patients with central venous catheters.

In this study we apply methods to determine the tendency for thrombus formation in different central venous catheters (CVC) models associated with flow rate variation. To calculate the thrombogenic potential, we proposed a new numerical model of the platelet lysis index (PLI) equation. To compare the results of PLI and flow rate in different models of catheters, numerical calculations were performed on three different tips of CVC.

Application of the educational method of realistic simulation in the treatment of pressure injuries.

Objective: to evaluate the use of realistic simulation as a strategy to promote teaching about pressure injuries.

Method: This is a quasi-experimental study. A modified and translated version of the Pieper Pressure Ulcer knowledge test was applied.

Molecular tracking of pathogens in central venous catheter.

Background: Central venous catheter-related bloodstream infection is an important adverse event in health care. Molecular methods are not yet substitutive of microbiological in the detection of the pathogens responsible for the infection, but they can help in the epidemiological characterization.

Aim: To detect bacteria by polymerase chain reaction, from material extracted from the tip of central catheters of patients suspected of infection at the intensive care unit.

Effect of the expression of CD62P and thrombin generation on patients using central venous catheters for hemodialysis.

The formation of thrombi in medical devices that come into contact with blood is a common cause of increased morbidity and mortality. Prolonged use of central venous catheters (CVCs) may cause high infection rates or compromise CVC patency due to thrombus development. In this study, we sought insights into possible changes in the hemostatic system during prolonged use of inserted CVCs for hemodialysis by assessing platelets by CD62P and CD41a expression and the potential for thrombin generation (TG).

Comparison of five methods of extraction of Staphylococcus aureus DNA for molecular detection by PCR.

Introduction: Molecular techniques for the detection of pathogens have been shown to be effective diagnostic tools with high sensitivity and short turnaround times.

Methods: This study compared five Staphylococcus aureus DNA extraction methods for detection by the polymerase chain reaction.

Results: The concentration and purity of the extracted DNA showed that the methods did not yield DNA of significant quality.

Microstructural evaluation by confocal and electron microscopy in thrombi developed in central venous catheters.

Objective: Evaluating thrombi microstructure developed in central venous catheters using confocal and electron microscopy.

Method: An experimental, descriptive study carrying out a microstructural evaluation of venous thrombi developed in central venous catheters using Scanning Electron Microscopy and Confocal Laser Scanning Microscopy.

Results: A total of 78 venous catheters were collected over a period of three months.

Quantification of fibrin in blood thrombi formed in hemodialysis central venous catheters: a pilot study on 43 CVCs.

Purpose: Fibrin deposition and thrombotic occlusion represent a serious cause of access dysfunction in hemodialysis central venous catheters (CVCs). The aim of this work was to define and apply a method for imaging and quantifying fibrin in thrombi formed into the side holes of CVCs.

Methods: Forty-three CVCs removed from a cohort of dialyzed patients were analyzed in this pilot study.

Blood flow in hemodialysis catheters: a numerical simulation and microscopic analysis of in vivo-formed fibrin.

Although catheters with side holes allow high flow rate during hemodialysis, they also induce flow disturbances and create a critical hemodynamic environment that can favor fibrin deposition and thrombus formation. This study compared the blood flow and analyzed the influence of shear stress and shear rate in fibrin deposition and thrombus formation in nontunneled hemodialysis catheters with unobstructed side holes (unobstructed device) or with some side holes obstructed by blood thrombi (obstructed device). Computational fluid dynamics (CFD) was performed to simulate realistic blood flow under laminar and turbulent conditions.

Hemodialysis catheter thrombi: visualization and quantification of microstructures and cellular composition.

Purpose: Despite the increasing use of central venous catheters (CVC) for hemodialysis in clinical practice, the role of CVC in thrombus development is poorly understood. This work aims at defining new methods and protocols for assessing the micromorphology and composition of thrombi formed into tunneled and non-tunneled hemodialysis CVC removed from patients. 


Methods: Twenty-nine CVCs were collected and the microscopic features of intra-luminal thrombi were quantified by scanning electron microscopy (SEM) and visualized by two photon laser scanning microscopy (TPLSM).

[Reprocessing validation of angiographic cardiac catheters: an evaluation of the functionality and integrity].

The objective of this study was to validate the reprocessing of angiographic cardiac catheters regarding their characteristics of mechanical functionality and the molecular and micro-structural integrity of the polymeric chain.This is an experimental, applied, comparative and controlled study. A simulation set was built for a left coronary angiography in order to simulate mechanical and biological stress in the catheters.