Differential effect of Incobotulinumtoxin A on pain, neurogenic flare and hyperalgesia in human surrogate models of neurogenic pain.

Background: The effectiveness of Botulinum-neurotoxin A (BoNT/A) to treat pain in human pain models is very divergent. This study was conducted to clarify if the pain models or the route of BoNT/A application might be responsible for these divergent findings.

Methods: Sixteen healthy subjects (8 males, mean age 27 ± 5 years) were included in a first set of experiments consisting of three visits: (1) Visit: Quantitative sensory testing (QST) was performed before and after intradermal capsaicin injection (CAPS, 15 μg) on one thigh and electrical current stimulation (ES, 1 Hz) on the contralateral thigh.

Computer-aided analysis of muscle fibre conduction velocity in neuromuscular diseases.

The objective was to measure muscle fibre conduction velocity (MFCV) in the biceps brachii of normal subjects, and patients with mild myopathies and anterior horn cell diseases. Unisolated steel needles served as stimulation and recording electrodes. By aid of a computer program for data acquisition and analysis, up to 1,400 single fibre potentials could be recorded from a single muscle and analysed within 30-45 min.