Inhibitor of Cysteine Protease of Regulates Malapains, Endogenous Cysteine Proteases of the Parasite.

Cysteine proteases of malaria parasites have been recognized as potential targets in antimalarial drug development as they play pivotal roles in the biology of these parasites. However, strict regulation of their activities is also necessary to minimize or prevent deleterious damage to the parasite and the host. Previously, we have characterized falcipain family cysteine proteases of , named as malapains (MPs).