PalmEx: Adding Palmar Force-Feedback for 3D Manipulation With Haptic Exoskeleton Gloves.

Haptic exoskeleton gloves are a widespread solution for providing force-feedback in Virtual Reality (VR), especially for 3D object manipulations. However, they are still lacking an important feature regarding in-hand haptic sensations: the palmar contact. In this paper, we present PalmEx, a novel approach which incorporates palmar force-feedback into exoskeleton gloves to improve the overall grasping sensations and manual haptic interactions in VR.

Prenatal diagnosis of a tetraploid fetus.

A tetraploid fetus with an unusual facial appearance and multiple congenital anomalies (large cerebral lateral ventricles; lung, cardiac, and genital abnormalities) is reported. Chromosome analysis was performed on amniocytes and fetal blood lymphocytes. A comparison is made with other reported cases (nine liveborn infants and one 17.

Natural killer cells are the unique lymphocyte cell subset which do not express HLA-G.

In order to better understand the immunological functions of the HLA-G gene, expression of this gene has been studied with RT-PCR in human functional lymphocyte subpopulations. Only one population of cells has not shown any HLA-G mRNA expression, the BY55-mAb-defined natural killer cells in cord blood. This absence of transcription was not modulated by IL2, IFN-gamma or TNF-alpha.

Evidence for the presence of the alternatively spliced HLA-G mRNA forms in human mononuclear cells from peripheral blood and umbilical cord blood.

The HLA-G monomorphic, nonclassic HLA class I gene encodes the molecule that is the only major histocompatibility complex antigen expressed on cytotrophoblasts of placenta. This restricted expression on fetal tissue that is in contact with maternal tissue suggests that HLA-G products may play a role in maternofetal tolerance. We previously have demonstrated in first-trimester human trophoblasts a new alternatively spliced form of HLA-G mRNA lacking exon 4 (HLA-G4) and weak expression of HLA-G1 copy mRNA in adult peripheral blood lymphocytes.

Soluble HLA-G molecule. An alternatively spliced HLA-G mRNA form candidate to encode it in peripheral blood mononuclear cells and human trophoblasts.

The HLA-G nonclassic MHC class I gene expressed at the maternal-fetal interface may be involved in cell protection against NK cell lysis. HLA-G mRNA is observed in different adult or fetal human cells and exhibits four alternative forms: HLA-G1, HLA-G2, HLA-G3, and HLA-G4 lacking, respectively, exon 7; exons 7 and 3, exons 7, 3, and 4; exons 7 and 4. Because exon 5 encodes the transmembrane domain of the HLA-G antigen, none of these transcripts could give a soluble form as detected in supernatant of trophoblasts.

46,XY/48,XYYY mosaicism case report and review of the literature.

A 46,XY (18.9%)/48,XYYY (81.1%) mosaicism in lymphocytes and a 48,XYYY karyotype in skin fibroblasts were found in a 37-year-old obese man suffering from dysplasia of the right hip.

HLA-G mRNA forms in human trophoblasts and peripheral blood lymphocytes: potential use in prenatal diagnosis.

HLA-G limited polymorphic gene maps to the human major histocompatibility complex (MHC) class I subregion and encodes the molecule which is the only MHC class I antigen expressed on cytotrophoblast cells at the maternal-fetal interface. In this tissue, HLA-G primary mRNA is differentially spliced. We have used a sensitive hot start reverse transcriptase-polymerase chain reaction (RT-PCR) technique to investigate the expression of HLA-G gene in first trimester trophoblasts and adult peripheral blood cells.

Case of (Y;1) familial translocation.

A balanced reciprocal translocation t(1;Y) (q11;q11) was found in an infertile man with severe oligoasthenospermia. The same translocation was found in his father. The role of X-chromosome inactivation during meiosis in a male carrying a Y;autosome translocation is discussed.

Monosomy 10qter: a new case.

A new case of terminal deletion 10q26-qter is described. The phenotypic features are compatible with those of the previously reported cases. Deafness is reported for the first time.

[Chromosome X with partial long arm deletion. Three cases].

X deletions result generally in one or many features characteristic of Turner syndrome but each feature cannot be attribute to a well defined deletion. We present 3 cases of Xq partial deletion: 2 in girls with primary amenorrhea and normal stature, 1 in a patient with secondary amenorrhea and short stature. X inactivation is a complex phenomenon, the mechanism is not yet clear.

Expression of c-fos and c-myc oncogenes in the P388D1 murine macrophage line treated by immunomodulators: absence of direct correlation with DNA synthesis.

Complex patterns of metabolic and functional characteristics are induced in macrophages by biological response modifiers. The study of the early events resulting from the transduction of immunomodulatory signals could be an approach for a better understanding of this activation process. The transcription of c-fos and c-myc genes has been shown to be rapidly modified in many cells responding to various signals.

C-fos and c-myc modulation, mitogenic effect and Ia expression in the P388D1 murine macrophage line treated by immunomodifiers.

The aim of the present study was to investigate whether the early modulation of the c-fos and c-myc oncogenes could give some orientation to the impact of immunomodulators on the monocyte-macrophage lineage. In order to work in a homogeneous system we used the P388D1 mouse macrophage cell-line which is considered as an almost mature macrophage. When P388D1 cells were stimulated by LPS, interferon-gamma or the association of both compounds, no direct correlation could be found between the modulation of DNA synthesis and the early expression of the c-fos and c-myc oncogenes.

Ring chromosome 17. Case report and review of the literature.

A 46,XX,r(17) karyotype was observed in a 9-year-old infant with short stature, moderate mental retardation but without other physical abnormality. Eight cases with an r(17) have since been reported: 4 can be compared with our patient, one was detected by amniocentesis, and 3 have Miller-Dieker syndrome. Submicroscopic deletions in the subband p13.

[Ring chromosome 3 in a mentally retarded adult dwarf].

A 46-year-old man with mental retardation, growth failure and some dysmorphic features is found to have a 46,XX,r(3)(p26q29) karyotype in 93% of his peripheral lymphocytes. This observation is compared with previously cases of ring 3. The existence of a "ring syndrome" is considered.

[Modifications, due to nutrition, of methyl and methylene 1H NMR signals in human plasma and normal serum samples].

The line width test has been realised on twelve normal healthy persons (seven men and five women). Blood was collected at different time during one day. The results obtained when blood samples was taking after eating, showed an appreciable decrease in the average methylene and methyl line width.

[In vitro differentiation of inflammatory and non-inflammatory states of the synovial fluid by magnetic protonic relaxation].

The differentiation between inflammatory and non inflammatory states has been performed using Nuclear Magnetic Resonance (NMR) in vitro by measuring relaxation times T1 and T2 in 84 synovials fluids obtained from various rheumatologic diseases. The results show that the T1/T2 ratio is more sensitive to distinguish these two situations rather than the isolated T1 or T2 values. In particular, high values of T1/T2 ratio are found in septic arthritis.

[Female karyotype and male phenotype: XX men. Apropos of 2 cases].

Males with a female karyotype are of special interest because they bear potential information on male determining factors leading to a masculine development in spite of a normal female chromosome constitution. We present 2 XX males, the clinical features correspond closely to many of those described in De La Chapelle's series of 46,XX males: reduced body height, infertility with small testicles, marked seminiferous tubular atrophy and azoospermia, slightly decreased testosterone level in serum and increased FSH and LH levels. Four main classes of theories concerning the etiology of XX males are presented, while mosaicism appears very unlikely in most cases, autosomal gene mutation, deletion or inactivation of X-chromosomal genes, X-Y interchange remain possible.

[Liquefaction of human sperm by a nuclear magnetic resonance technic. Effect of temperature].

An investigation of the liquefaction of human semen was performed using the technique of Nuclear Magnetic Resonance, by measuring the time of spin-spin proton relaxation. Measurements which were made at 24 degrees C and 37 degrees C over a 15-day period showed that significant degradation processes and protein transformations occurred during the first 3-5 days. Different phases of these processes were identified.

Liquefaction of human semen by spin-spin proton relaxation technique.

An investigation of the liquefaction of human semen was performed using a technique of nuclear magnetic resonance, by measuring the time of spin-spin proton relaxation. Measurements made at 24 degrees C over a 15-day period showed that significant degradation processes and protein transformations occurred during the first 5 days. Different phases of these processes were identified.

[Familial transmission of deleted chromosome 22 [r(22)p0?] in two normal women].

A deleted chromosome 22 resembling a ring chromosome was found in a 27-year-old woman without dysmorphic features nor mental retardation. A similar chromosome was found in her mother.

[Value of silver staining technics for the study of acrocentric ring chromosomes and supernumerary microchromosomes].

The silver staining techniques was used to study two cases of ring chromosomes (ring chromosome 15 and ring chromosome 22) and two cases of small extra chromosomes. This technique allows identification of the breakpoints and provides some information about the origin of small extra chromosomes.