Publications by authors named "Tewabe Kebede"
Article Synopsis
- Amyloidosis derived from apolipoprotein C-II (AApoCII) is a rare condition that primarily affects the kidneys, presenting with symptoms like proteinuria and reduced kidney function, particularly in older patients.
- A study conducted with 25 cases from the Mayo Clinic revealed common histological characteristics, such as nodular amyloid deposits in glomeruli, and proteomic analysis identified specific Apo C-II variants in many patients.
- Despite significant kidney issues, including end-stage kidney disease in about half of the patients, the overall survival rate was more favorable, indicating potential for better outcomes in this condition.
Hypertensive disorders of pregnancies remain a central public health concern throughout the world, and are a major cause of maternal mortality in the developing world. Although treatment options have not significantly changed in recent years, insight on the pathogenesis of preeclampsia/eclampsia has been remarkable. With improved animal models of preeclampsia and large-scale human trials, we have embarked upon a new era where angiogenic biomarkers based on mechanism of disease can be designed to assist in early diagnosis and treatment.
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- There is a significant lack of reliable diagnostic markers for early-stage ovarian cancer (OVCA), prompting a study to evaluate the presence of specific antibodies in patients with OVCA.
- The study used serum samples from various groups such as OVCA patients, benign tumor patients, and healthy women to assess the presence of anti-ovarian and anti-tumor antibodies through immunoassays.
- Results showed that women with OVCA had a notably higher prevalence of ovarian (81%) and anti-tumor (69%) autoantibodies compared to control groups, suggesting that these antibodies could be potential biomarkers for ovarian cancer detection.
Anti-tumor antibodies have potential as cancer biomarkers. There is relatively limited identification of anti-tumor antibodies in response to ovarian cancer, compared with studies for other cancers. There is also very limited information on the prevalence of anti-tumor antibodies among ovarian cancer patients.
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