Release characteristics of salmon calcitonin from dextran hydrogels for colon-specific delivery.

Biodegradable dextran hydrogels were synthesized by crosslinking dextran (T-70) with epichlorohydrin (ECH) for the in vitro colon-specific delivery of salmon calcitonin (sCT). Crosslinking reaction was performed in 2.8 M NaOH solution both in the presence and absence of ethanol at 10 and 23 degrees C.

Diclofenac sodium releasing pH-sensitive monolithic devices.

A non-steroidal anti-inflammatory agent, diclofenac sodium (DFNa), was incorporated into the pH-sensitive monolithic systems prepared by crosslinking/copolymerization of 2-hydroxyethyl methacrylate (HEMA) with acrylate-based acidic and basic comonomers, i.e. acrylic acid (AA) and dimethylaminoethyl methacrylate (DMAEMA).