Publications by authors named "Teuta Zoto"
Background: Polymorphisms in the genes encoding alcohol metabolizing enzymes are associated with alcohol dependence.
Aim: To evaluate the association between the alcohol dehydrogenase 1C (ADH1C) Ile350Val and aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphisms and alcohol dependence in a Turkish sample.
Methods: 235 individuals (115 alcohol-dependent patients and 120 controls) were genotyped for ADH1C and ALDH2 with PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism).
Chemotherapy-induced nausea and vomiting (CINV) remains a major adverse effect decreasing quality of life in patients with cancer. Genetic variations among patients may be responsible for part of the lack of efficacy of anti-emetic drugs. The aim of this study was to investigate how the genetic variants of the drug transporter ABCB1 (MDR1) gene affect anti-emetic treatment with 5-HT3 receptor antagonists.
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- Pseudohypoparathyroidism type-Ia (PHP-Ia) is caused by maternal mutations in the GNAS gene, resulting in a loss of function of Gαs, leading to resistance to parathyroid hormone (PTH) and hypocalcemia.
- The PTH resistance in PHP-Ia manifests after early postnatal life, indicating that the silencing of the paternal Gαs allele in kidney cells occurs gradually rather than immediately after birth.
- Studies show that while Gαs expression is mostly from the maternal allele in adulthood, both maternal and paternal alleles contribute equally at a postnatal age of 3 days, highlighting a delayed onset of PTH resistance in PHP-Ia patients.
Transactivation of epidermal growth factor receptor (EGFR) by α1-adrenoceptor (α1-AR) is implicated in contraction and hypertrophy of vascular smooth muscle (VSM). We examine whether all α1-AR subtypes transactivate EGFR and explore the mechanism of transactivation. Chinese hamster ovary (CHO) cells stably expressing one subtype of α1-AR were transiently transfected with EGFR.
View Article and Find Full Text PDFThe constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters and erythrocyte functioning.
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