Publications by authors named "Tetsuyuki Tateda"
Gut microbiota involvement in the effect of water-soluble dietary fiber on fatty liver and fibrosis.
Biosci Microbiota Food Health
August 2024
The beneficial effects of water-soluble dietary fiber on liver fat and fibrosis involve the gut microbiota; however, few epidemiological studies have investigated this association. This large-scale epidemiological study aimed to determine the effect of water-soluble dietary fiber intake on liver fat and fibrosis via gut microbiota for the general population. We divided low- and high-intake groups by median daily water-soluble dietary fiber intake and matched background factors by propensity score matching for sex and age.
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- This study examined how different Japanese dietary patterns affect metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis in 727 adults.
- Participants' diets were categorized into rice, vegetable, seafood, and sweet groups, revealing that those in the vegetable group had lower indicators of liver fibrosis compared to the rice group.
- The research identified body mass index ≥ 25 kg/m and HOMA-IR ≥ 1.6 as risk factors for liver fibrosis, while a vegetable-based diet, high in α-tocopherol (an antioxidant), was associated with a lower risk of developing liver fibrosis.
Introduction: Esophageal achalasia is a typical esophageal motility disorder (EMD). Although viral infections have been hypothesized to play a role in the pathogenesis of esophageal achalasia, its etiology remains unclear. This study used esophageal muscle layer specimens collected during per-oral endoscopic myotomy (POEM) procedures to investigate the association between esophageal achalasia and esophagogastric junction outflow obstruction (EGJOO) and pattern recognition receptors.
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- The study investigates the relationship between liver fibrosis and reactive oxygen species (ROS) levels produced by neutrophils, focusing on how this varies with age and sex in the general population.
- It involved 1,000 participants categorized into four groups based on sex and age, using various indices to assess liver fibrosis.
- Findings indicated positive correlations between liver fibrosis scores and basal ROS levels in younger participants, while in females, higher liver fibrosis scores were associated with lower stimulated ROS levels, suggesting that enhancing neutrophil function could help prevent liver-related diseases.
Article Synopsis
- * After matching participants based on various health factors, researchers found significant differences in gut microbiota diversity between those with and without liver fibrosis, but no notable differences in oral microbiota.
- * The results suggest that gut microbiota may play a more significant role in liver fibrosis than oral microbiota, although certain strains didn't independently influence liver fibrosis when adjusting for other health variables.
Article Synopsis
- The study aimed to assess the clinical characteristics of metabolic dysfunction-associated fatty liver disease (MAFLD) and its usefulness in a health survey context among 1056 participants.
- Findings showed that 88.1% of participants had MAFLD compared to 75.5% with nonalcoholic fatty liver disease (NAFLD), with those having a higher FAST score more likely to have MAFLD.
- The research identified significant dietary differences in participants with MAFLD, highlighted low levels of the bacteria Blautia, and suggested that MAFLD criteria could improve screening for liver fibrosis and high-risk fatty liver conditions.
Article Synopsis
- * In a study of 684 adults, 40% had NAFLD, with 43% identified as equol producers; however, only 33% of those with lean NAFLD were equol producers, highlighting a notable difference in male participants at only 8%.
- * The gut microbiota of equol producers showed significant differences compared to nonproducers, including an increased abundance of specific bacteria associated with equol production, suggesting a critical role in the pathology of lean NAFLD among men.