Publications by authors named "Tetsuya Nakajo"
Article Synopsis
- - The study compares the effects of organ preservation using histidine-tryptophan-ketoglutarate (HTK) and UW solutions, specifically focusing on the ultrastructural changes in hepatocytes after machine perfusion (MP).
- - Ultrastructural evaluations revealed that both hypothermic (HMP) and midthermic (MMP) preservation methods maintained mitochondrial functionality, but HMP showed better results with denser mitochondrial cristae and autophagosome presence after simulated liver graft reperfusion.
- - These results challenge prior conclusions about UW solution, indicating that HMP with HTK may be more effective than MMP, suggesting a need for careful optimization of perfusion conditions before switching preservation methods. *
Grafts from donors after cardiac death (DCD) have greatly contributed to expanding the donor organ pool. This study aimed to determine the benefits of subnormothermic extracorporeal membrane oxygenation (ECMO) and hypothermic machine perfusion (HMP) in a porcine model of DCD liver. Female domestic crossbred Large Yorkshire and Landrace pigs weighing approximately 20 kg were used.
View Article and Find Full Text PDFBackground: The use of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. This study aims to determine the benefits of extracorporeal membrane oxygenation (ECMO) and hypothermic oxygenated machine perfusion (HOPE) in a large animal model of DCD liver.
Methods: After cardiac arrest, the abdominal aorta and the inferior vena cava were cannulated and connected to an ECMO circuit.
Improvement of machine perfusion (MP) technologies is required to enhance organ quality for donor after cardiac death (DCD) grafts. Installing a dialyzer or a filter into the perfusion circuit to maintain the perfusate condition has some advantages. However, the consequences of purification perfusate during subnormothermic machine perfusion (SNMP) remain unexplained.
View Article and Find Full Text PDFObjective: To investigate the short-term effects of infrapatellar fat pad (IFP) resection in normal dogs.
Study Design: Experimental in vivo study.
Animals: Five normal adult female beagle dogs.