Publications by Tetsuya Kokuta

Publications by authors named "Tetsuya Kokuta"

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Mitotic cells can repair DNA double-strand breaks via a homology-directed pathway.

Yuki Sakamoto Tetsuya Kokuta Ai Teshigahara Kenta Iijima Hiroyuki Kitao

J Radiat Res

January 2021

The choice of repair pathways of DNA double-strand breaks (DSBs) is dependent upon the cell cycle phases. While homologous recombination repair (HRR) is active between the S and G2 phases, its involvement in mitotic DSB repair has not been examined in detail. In the present study, we developed a new reporter assay system to detect homology-directed repair (HDR), a major pathway used for HRR, in combination with an inducible DSB-generation system.

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- Tetsuya Kokuta's recent research focuses on the mechanisms of DNA double-strand break (DSB) repair in mitotic cells, specifically examining the role of homology-directed repair (HDR) pathways.
- In his 2021 study published in the Journal of Radiation Research, Kokuta developed a novel reporter assay system to investigate HDR activity during different phases of the cell cycle, including the S and G2 phases.
- The findings indicate that the choice of DSB repair pathways is phase-dependent, highlighting the need for further exploration of HDR mechanisms in mitotic DSB repair processes.

Publications by authors named "Tetsuya Kokuta"

Mitotic cells can repair DNA double-strand breaks via a homology-directed pathway.

Synopsis of recent research by authors named "Tetsuya Kokuta"