The Efficacy and Safety Associated with Switching from Concomitant Brimonidine and Ripasudil, or Brimonidine or Ripasudil Monotherapy to a Fixed Combination of Brimonidine and Ripasudil in Glaucoma Patients.

: The purpose of this study was to investigate switching from brimonidine and ripasudil, and brimonidine or ripasudil, to a fixed combination of brimonidine and ripasudil, and evaluate the associated efficacy and safety in glaucoma patients. : Glaucoma patients undergoing treatment with at least brimonidine and ripasudil (n = 25) or treatment with at least brimonidine or ripasudil (n = 45) were evaluated in this retrospective study. After switching patients taking brimonidine and ripasudil, or brimonidine or ripasudil, to a ripasudil/brimonidine fixed-combination, ophthalmic suspension (RBFC), intra-ocular pressure (IOP), conjunctival hyperemia and superficial punctate keratopathy (SPK) were evaluated before and at 4, 12 and 24 weeks after switching to RBFC.

Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study.

Background: To investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.

Methods: This prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent trabeculectomy or trabeculectomy combined with cataract surgery followed by 3-month postoperative ripasudil treatments. After randomly allocating patients to ripasudil-ROCK inhibitor (ripasudil) or without ripasudil (non-ripasudil) groups.

Microstructurally Tailored Thin β-Ag Se Films toward Commercial Flexible Thermoelectrics.

Aiming to overcome both the structural and commercial limitations of flexible thermoelectric power generators, an efficient room-temperature aqueous selenization reaction that can be completed in air within less than 1 min, to directly fabricate thin β-Ag Se films consisting of perfectly crystalline and large columnar grains with both in-plane randomness and out-of-plane [201] preferred orientation, is designed. A high power factor (PF) of 2590 ± 414 µW m K and a figure-of-merit (zT) of 1.2 ± 0.

Flexible -Type Abundant Chalcopyrite/PEDOT:PSS/Graphene Hybrid Film for Thermoelectric Device Utilizing Low-Grade Heat.

Combining inorganic thermoelectric (TE) materials with conductive polymers is one promising strategy to develop flexible thermoelectric (FTE) films and devices. As most inorganic materials tried up until now in FTE composites are composed of scarce or toxic elements, and -type FTE materials are particularly desired, we combined the abundant, inexpensive, nontoxic Zn-doped chalcopyrite (CuZnFeS, = 0.01, 0.

Thermoelectric Performance Enhancement of Film by Pulse Electric Field and Multi-Nanocomposite Strategy.

Thermoelectric (TE) film has wide potential application in low-grade waste heat recovery and TE generation due to its quick response and multifunctional integration. Multi-nanocomposite is a promising method to solve the difficulty of maintaining temperature difference and achieving a high figure of merit ZT. However, the depletion layer induced by the multi-nanocomposite typically degrades performance.

Drastic power factor improvement by Te doping of rare earth-free CoSb-skutterudite thin films.

In the present study, we have focused on the elaboration of control of Te-doped CoSb thin films by RF magnetron sputtering which is an attractive technique for industrial development of thermoelectric (TE) thin films. We have successfully synthesized sputtering targets with a reliable approach in order to obtain high-quality films with controlled stoichiometry. TE properties were then probed and revealed a reliable n-type behavior characterized by poor electrical transport properties.

Experimental investigation of reciprocity of temperature response across two layer samples by flash method.

The reciprocity of heat transfer is a fundamental principle. However, there are few experimental studies to verify this principle. In this paper, we measured two layer samples made of ordinary metal by the laser flash method to verify the reciprocity principle.

Characteristics of early filtering blebs that predict successful trabeculectomy identified via three-dimensional anterior segment optical coherence tomography.

Background/aims: To identify the cross-sectional characteristics of filtering blebs at 2 weeks post-trabeculectomy associated with intraocular pressure (IOP) control at 1 year post-trabeculectomy.

Methods: Ninety-nine eyes of 94 patients who had undergone primary trabeculectomy were included in this retrospective consecutive case series study. Surgical success was defined as an IOP ≤15 mm Hg and a >20% reduction in IOP without glaucoma medication or additional glaucoma surgeries at 1 year post-trabeculectomy.

The signs of ocular-surface disorders after switching from latanoprost to tafluprost/timolol fixed combination: a prospective study.

Purpose: To evaluate the ocular-surface safety of a 0.001% benzalkonium chloride-containing tafluprost/timolol fixed combination (TTFC) in patients with primary open-angle glaucoma (POAG) or ocular hypertension who have inadequate intraocular pressure (IOP) control with latanoprost monotherapy.

Methods: This study is a multicenter, prospective, single-arm, open-label clinical study.

Characteristics of successful filtering blebs at 1 year after trabeculectomy using swept-source three-dimensional anterior segment optical coherence tomography.

Purpose: To identify the cross-sectional characteristics of filtering blebs associated with intraocular pressure (IOP) control at 1 year after trabeculectomy with a square scleral flap and a fornix-based conjunctival flap.

Methods: A retrospective consecutive case series study was conducted. Eighty-four eyes of 79 patients who had undergone primary trabeculectomy were included.

Evaluation of relationship between retinal nerve fiber layer thickness progression and visual field progression in patients with glaucoma.

Purpose: To evaluate the capability of optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thickness, and visual field (VF) measurements in glaucoma progression detection.

Methods: The study examined 62 eyes of 37 glaucoma patients observed over a 3-year period. All eyes underwent at least four serial RNFL measurements performed by Cirrus OCT, with the first and last measurements separated by at least 3 years.

Correlation between the ganglion cell-inner plexiform layer thickness measured with cirrus HD-OCT and macular visual field sensitivity measured with microperimetry.

Purpose: To evaluate relationships between the macular visual field (VF) mean sensitivity and the ganglion cell and inner plexiform layer (GCA) thicknesses.

Methods: Seventy-one glaucoma patients and 29 healthy subjects were included in this cross-sectional study. At each visit, GCA thicknesses were measured by Cirrus HD-OCT and static threshold perimetry was performed using Macular Integrity Assessment (MAIA).

Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma.

Background: To compare peripapillary choroidal thickness measurements between normal and normal-tension glaucoma eyes.

Methods: Cross-sectional comparative study. 50 normal and 52 normal-tension glaucoma subjects were enrolled in the study.

Comparison of optic nerve head parameters using Heidelberg Retina Tomograph 3 and spectral-domain optical coherence tomography.

Background:   To assess the agreement between the Heidelberg Retina Tomograph and Cirrus spectral-domain optical coherence tomography (Cirrus HD-OCT [Carl Zeiss Meditec, Dublin, CA, USA]) when measuring optic disc parameters.

Design:   Prospective, cross-sectional study.

Participants:   A total of 96 glaucoma patients and 21 normal subjects were analysed.

Relationship between progression of visual field damage and choroidal thickness in eyes with normal-tension glaucoma.

Background:   To measure choroidal thickness in normal eyes and in patients with normal-tension glaucoma using enhanced depth imaging optical coherence tomography and evaluate the association between choroidal thickness and progression of visual field damage.

Design:   Cross-sectional comparative study.

Participants:   A total of 62 eyes of 62 normal subjects and 45 eyes of 45 normal-tension glaucoma patients were examined.

Efficacy and safety of switching from topical latanoprost to bimatoprost in patients with normal-tension glaucoma.

Purpose: The aim of this study was to evaluate the efficacy and safety of bimatoprost in Japanese patients with normal-tension glaucoma (NTG) who showed insufficient response to latanoprost.

Methods: A prospective, nonrandomized study was conducted in patients with NTG, with ≤20% intraocular pressure (IOP) decrease from pretreatment baseline with latanoprost monotherapy who had been switched to bimatoprost. The IOP was measured at 4, 8, and 12 weeks after the switch to bimatoprost.

Comparison of retinal nerve fiber layer thickness measurements using time domain and spectral domain optical coherence tomography, and visual field sensitivity.

Purpose: To investigate the relationship between the peripapillary retinal nerve fiber layer (RNFL) thickness, as measured by Stratus time domain optical coherence tomography (OCT) (Stratus OCT) and Cirrus spectral domain OCT (Cirrus HD-OCT), and the severity indices of the visual field (VF) defects in glaucoma patients.

Methods: This was a prospective, cross-sectional study. Correlations between the individual VF sensitivity at 52 test points and the Stratus OCT and Cirrus HD-OCT, which determined peripapillary RNFL thicknesses from 6 sectors, were calculated in 54 eyes with open-angle glaucoma and 22 normal control eyes.

Comparison of ICare rebound tonometer with noncontact tonometer in healthy children.

Purpose: To evaluate the effectiveness of using a noncontact tonometer (NCT) versus a rebound tonometer (ICare) when measuring the intraocular pressure (IOP) in healthy children.

Design: Prospective observational study.

Methods: A total of 180 (96 males and 84 females) healthy children, aged 6 months to 15 years, were recruited.

Effect of trabeculectomy on intraocular pressure fluctuation with postural change in eyes with open-angle glaucoma.

Purpose: To investigate the effect of trabeculectomy on the intraocular pressure (IOP) fluctuations caused by the postural change in patients with open-angle glaucoma.

Methods: Prospective, nonrandomized study. Ten eyes of 10 patients with primary open-angle glaucoma and 3 eyes of 3 patients with normal-tension glaucoma who underwent trabeculectomy were studied.

Risk factors for developing avascular filtering bleb after fornix-based trabeculectomy with mitomycin C.

Purpose: To investigate risk factors for developing avascular filtering blebs after primary fornix-based trabeculectomy with mitomycin C (MMC).

Methods: One-year observational case series. Ninety eyes of 90 patients who underwent primary trabeculectomy with MMC and a fornix-based conjunctival flap were examined.

Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits.

Purpose: To investigate the pharmacokinetics of bevacizumab in rabbits for three different routes of administrations: intravitreal injection, subconjunctival injection, and eye drops.

Methods: Pigmented rabbits received bevacizumab in one eye by topical eye drops (1.25 mg/0.

Stratus optical coherence tomography study of filtering blebs after primary trabeculectomy with a fornix-based conjunctival flap.

Purpose: To investigate the relationship between filtering bleb function and Stratus optical coherence tomography (OCT) images.

Methods: We studied 72 eyes of 65 consecutive patients who had a fornix-based conjunctival flap in primary trabeculectomy with mitomycin C (MMC). Filtering blebs with various types of glaucoma were examined using Stratus OCT.