Publications by authors named "Tetsushi Sakiyama"
Article Synopsis
- - The study discusses STA551, a novel anti-CD137 switch antibody that activates only in the presence of extracellular adenosine triphosphate (exATP), focusing on its potential to overcome limitations seen in previous CD137 agonists which suffered from toxicity and specificity issues.
- - STA551 showed strong antitumor effects across various mouse and human tumor models without causing systemic immune activation, indicating a wide therapeutic window and good tolerability even at high doses in monkeys.
- - The findings suggest STA551 could be a promising treatment option for a broad range of cancers, as it does not rely on specific tumor antigens for efficacy, paving the way for its clinical testing and future developments in cancer therapy.
Article Synopsis
- * Researchers developed SKY59, a new humanized antibody that uses pH-dependent binding to C5, allowing for longer-lasting neutralization of the complement system compared to conventional treatments.
- * SKY59 demonstrated a novel mechanism of interaction with C5, showing effectiveness against specific C5 variants that eculizumab does not address, making it a promising alternative for patients with complement-mediated disorders.
A glucose-tolerant strain of the cyanobacterium Synechocystis sp. PCC 6803, generally referred to as wild type, produces a hemolysin-like protein (HLP) located on the cell surface. To analyze the function of HLP, we constructed a mutant in which the hlp gene was disrupted.
View Article and Find Full Text PDFThe hemolysin-like protein (HLP) Sll1951, characterized by the GGXGXDXUX nonapeptide motif implicated in Ca(2+) binding, was purified from the glucose-tolerant strain (GT) of Synechocystis sp. strain PCC 6803. HLP was eluted at 560 kDa after gel filtration chromatography.
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