Intravitreal injection of triamcinolone acetonide to treat cystoid foveal edema associated with coats' disease.

Purpose: To investigate the efficacy of intravitreal injection of triamcinolone acetonide (TA) for treatment of cystoid foveal edema (CFE) associated with Coats' disease.

Methods And Patient: A 32-year-old man with a 28-month history of Coats' disease received an intravitreal TA injection (4 mg) in the right eye.

Results: Visual acuity improved from 20/200 to 20/50, and foveal thickness decreased from 701 μm to 216 μm 45 days after treatment.

Macular hole with epiretinal membrane after triamcinolone-assisted vitrectomy for proliferative diabetic retinopathy.

Background: We described three cases of macular holes with an epiretinal membrane that developed after triamcinolone-assisted vitrectomy for proliferative diabetic retinopathy (PDR).

Case Reports: In case 1, vitrectomy was performed for vitreous hemorrhage and tractional retinal detachment. In case 2 and 3, vitrectomy was performed for vitreous hemorrhage.

Retinal sensitivity loss and structural disturbance in areas of capillary nonperfusion of eyes with diabetic retinopathy.

Purpose: To assess light sensitivity and morphologic changes of capillary nonperfused areas in diabetic retinopathy.

Design: Prospective, observational cross-sectional study.

Methods: Seventeen consecutive patients (20 eyes) with areas of capillary nonperfusion resulting from severe nonproliferative or proliferative diabetic retinopathy were included in the study.

Comparisons between the beneficial effects of different sulphonylurea treatments on ischemia-induced retinal neovascularization.

The aim of this study was to assess the potential beneficial effects of gliclazide and other sulphonylureas on ischemia-induced retinal neovascularization. To produce an animal model of oxygen-induced ischemic retinopathy, 7-day-old (P7) mice were exposed to a 75% oxygen environment for 5 days. On their return to ambient air at P12, these mice were then treated with gliclazide, glibenclamide, glimepiride, or N-acetylcysteine.

Time-lapse imaging of vitreoretinal angiogenesis originating from both quiescent and mature vessels in a novel ex vivo system.

Purpose: Diabetic retinopathy (DR) is an angiogenic disease that leads to severe visual loss. However, adequate animal models of vitreoretinal neovascularization in proliferative diabetic retinopathy (PDR) have not yet been described. The purpose of this study was to develop a novel ex vivo system for assessing vitreoretinal angiogenic processes that originate from both quiescent and mature vessels that could be observed with time-sequential imaging.

Efficacy of surgical removal of the internal limiting membrane in diabetic cystoid macular edema.

Purpose: To evaluate the efficacy of surgical removal of the internal limiting membrane (ILM) in diabetic cystoid macular edema (CME).

Methods: Prospective, noncomparative, interventional case series including 21 eyes of 18 consecutive patients with diabetic CME. Vitrectomy with separation of the posterior hyaloid and induction of posterior vitreous detachment had been performed previously on nine eyes.

Vitreous levels of angiopoietin 2 and vascular endothelial growth factor in patients with proliferative diabetic retinopathy.

Purpose: To investigate the levels of angiopoietin-2 (Ang2) and vascular endothelial growth factor (VEGF) in the vitreous fluids of patients with proliferative diabetic retinopathy (PDR) and to ascertain their involvement, if any, in angiogenesis of PDR.

Design: Retrospective case-control study.

Methods: Forty-one eyes of 41 patients with proliferative diabetic retinopathy and 18 eyes of 18 patients with nondiabetic ocular diseases (control group).

Is removal of internal limiting membrane always necessary during stage 3 idiopathic macular hole surgery?

Purpose: To determine the indications for internal limiting membrane (ILM) removal in stage 3 idiopathic macular holes (MHs).

Methods: Focal posterior vitreous detachments (PVDs) at MH rims were examined preoperatively by optical coherence tomography and binocular slit-lamp fundus examination in 19 patients retrospectively. All eyes underwent pars plana vitrectomy and creation of a PVD, and some eyes underwent a second surgery to remove the ILM.