Edge-strand of BepA interacts with immature LptD on the β-barrel assembly machine to direct it to on- and off-pathways.

The outer membrane (OM) of Gram-negative bacteria functions as a selective permeability barrier. periplasmic Zn-metallopeptidase BepA contributes to the maintenance of OM integrity through its involvement in the biogenesis and degradation of LptD, a β-barrel protein component of the lipopolysaccharide translocon. BepA either promotes the maturation of LptD when it is on the normal assembly pathway (on-pathway) or degrades it when its assembly is compromised (off-pathway).

Comparison of range of motion during movement from supine to sitting position in healthy young and elderly participants.

[Purpose] The purpose of this study was to compare the range of motion (ROM) during supine-to-sitting position (StSP) movement between healthy young and elderly participants to understand age-related tendencies, which is beneficial for the assessment and treatment of frail elderly. [Participants and Methods] The participants were 14 healthy young males (age, 19-24 years) and 16 healthy elderly individuals (8 males and 8 females; age, 65-74 years). Rising movement was performed 5 times freely at a comfortable speed.

Stabilizing transpelvic prosthetic socket for a patient with spinal cord injury sustaining right partial hemipelvectomy and left hip disarticulation.

A bucket-type transpelvic socket was fabricated for a man with paraplegia from spinal cord injury, who underwent right partial pelvic amputation and left hip disarticulation. His main problem was inability to sit due to asymmetrical pelvic shape. We prescribed a transpelvic prosthetic socket to enable him to sit again.