Publications by authors named "Tetsuro Tamehisa"
Article Synopsis
- Dose-dense paclitaxel/carboplatin (ddTC) therapy was initially thought to be more effective for treating ovarian cancer than the traditional tri-weekly TC, based on the JGOG3016 study, although later studies showed mixed results.
- A retrospective analysis of patients treated with ddTC from 2012 to 2018 revealed high response rates (RRs) and progression-free survival (PFS) times, with front-line treatment achieving an RR of 82.9% and a median PFS of 20 months.
- Overall, ddTC therapy showed strong effectiveness in managing advanced stages (III and IV) of ovarian cancer, providing promising outcomes for both first-line and platinum-sensitive relapse treatments.
Purpose: To investigate whether long noncoding RNAs (lncRNAs) are involved in the development or malignant behavior of ovarian high-grade serous carcinoma (HGSC), we attempted to identify lncRNAs specific to HGSC.
Methods: Total RNAs were isolated from HGSC, normal ovarian, and fallopian tube tissue samples and were subjected to a PCR array that can analyze 84 cancer-associated lncRNAs. The lncRNAs that were upregulated and downregulated in HGSC in comparison to multiple samples of normal ovary and fallopian tube were validated by real-time RT-PCR.
Objective: To establish prediction models for the diagnosis of the subtypes of uterine leiomyomas by machine learning using magnetic resonance imaging (MRI) data.
Methods: This is a prospective observational study. Ninety uterine leiomyoma samples were obtained from 51 patients who underwent surgery for uterine leiomyomas.
Somatic mutations in Mediator complex subunit 12 (MED12m) have been reported as a biomarker of uterine fibroids (UFs). However, the role of MED12m is still unclear in the pathogenesis of UFs. Therefore, we investigated the differences in DNA methylome, transcriptome, and histological features between MED12m-positive and -negative UFs.
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- - The study aimed to find long non-coding RNAs (lncRNAs) that are expressed unusually in ovarian high-grade serous carcinoma (HGSC) by analyzing RNA from various ovarian cell types.
- - Using a PCR array, researchers pinpointed ten lncRNAs with altered expressions in HGSC cell lines—six were upregulated and four downregulated—and tested their effects on cell activities like proliferation, migration, and apoptosis.
- - They discovered that overexpressing certain lncRNAs (MEG3 and POU5F1P5) inhibited cell migration, and the same four downregulated lncRNAs were also found to be low in actual HGSC tissue samples, indicating their potential significance in ovarian cancer.