A new algorithm to convert a normal antibody into the corresponding catalytic antibody.

Over thousands of monoclonal antibodies (mAbs) have been produced so far, and it would be valuable if these mAbs could be directly converted into catalytic antibodies. We have designed a system to realize the above concept by deleting Pro, a highly conserved residue in CDR-3 of the antibody light chain. The deletion of Pro is a key contributor to catalytic function of the light chain.