[A case of sigmoid colon cancer, successfully treated by a multidisciplinary strategy for local recurrence and distant metastases].

We report a case of sigmoid colon cancer, successfully treated by a multidisciplinary strategy for local recurrence and distant metastases. This 60-year-old male patient underwent sigmoidectomy for sigmoid colon cancer. Three years after the operation, local recurrence with invasion to the left ureter was found, and we performed colectomy and left nephroureterectomy.

[A case of advanced rectal cancer with lung and bone metastasis that was successfully treated with mFOLFOX6+bevacizumab].

A 48-year-old man with respiratory discomfort was diagnosed with rectal cancer with carcinomatous lymphangiosis, together with lung and sternum metastasis. As the patient's performance status(PS) was 2, mFOLFOX6+bevacizumab (Bmab)therapy with a 20% reduction in the dose was started. Three courses of this treatment resulted in improved respiratory function, and his PS dropped to 1.

Resection with en bloc removal of regional lymph node after endoscopic resection for T1 colorectal cancer.

Background: Various guidelines suggest indications for performing additional colectomy with en bloc removal of regional lymph nodes after endoscopic resection for T1 colon cancer. The aim of this study was to evaluate the pathologic outcomes of patients with surgical treatment after endoscopic resection for T1 colorectal cancer.

Methods: We used data from 275 patients who had undergone curative resection for T1 colorectal cancer at a single institution between 1991 and 2009.

PIK3CA mutation and methylation influences the outcome of colorectal cancer.

Colorectal cancer (CRC) occurs through the accumulation of genetic and epigenetic alterations. The epigenetic abnormalities, in cooperation with genetic alterations, are capable of causing aberrant gene function that results in cancer. In the present study, we examined mutations and methylation status in 164 CRCs to determine whether the combination of genetic and epigenetic alterations may be used to classify CRC patients in relation to their clinicopathological characteristics and outcomes.

Laparoscopic-assisted colectomy in a patient with colon cancer after percutaneous endoscopic gastrostomy.

Background: A number of patients undergo percutaneous endoscopic gastrostomy (PEG) under various conditions. Open colectomy is usually performed for colon cancer in patients with PEG because the safety of the laparoscopic approach for such patients has not been established. However, if the laparoscopic approach is possible in patients with PEG, it will be less invasive and more helpful in rehabilitation into society.

[A surgical case of descending colon cancer with abdominal wall abscess after drainage of abscess].

We report a surgical case of descending colon cancer with abdominal wall abscess. A 72-year-old man was admitted to a hospital because of left lower abdominal mass with slight pain. An abdominal CT showed a left lower abdominal wall abscess adjacent to the descending colonic wall thickening.

[Repeated resections for originally unresectable liver metastasis from colorectal cancer after multiagent chemotherapy].

We describe the case of a 74-year-old man with liver resection for originally unresectable liver metastasis from colorectal cancer after multiagent chemotherapy. Eleven bilobar liver metastases appeared four months after curative resection for double cancer of sigmoid colon and upper rectum. After 6 courses of multiagent chemotherapy (mFOLFOX 6 with bevacizumab), the number of liver metastasis decreased from 11 to 5.

[Multidisciplinary treatment including pneumonectomy for squamous cell carcinoma of the anal canal-a case report].

In August 2008, a 52-year-old woman presented to our hospital with a complaint of bleeding upon defecation. The patient underwent lower gastrointestinal endoscopy with biopsy. PRb indicated a type 2 lesion in one-third of the circumference.

[A long-term survival case of neuroendocrine tumor of the sigmoid colon with multiple liver metastases].

It has been reported that neuroendocrine tumor (NET) of the large intestine with distant metastasis is rare and carries poor prognosis. We report a case of colonic NET with hepatic metastases, who was successfully treated by combined therapy. A 71-year-old man with sigmoid colon tumor underwent sigmoidectomy and histopathological examination disclosed the tumor was NET grade 1.

[A case of colonic neuroendocrine carcinoma with severe liver dysfunction by multiple liver metastases successfully treated with hepatic arterial infusion].

A 63-year-old male was diagnosed as ascending colon cancer with severe liver dysfunction caused by multiple liver metastases. Initially, hepatic arterial infusion (HAI) chemotherapy was started to reduce the size of metastatic tumors and to prevent a liver failure. After 7 courses of HAI chemotherapy, he recovered from liver dysfunction, and underwent right hemicolectomy.

Clinical significance of UNC5B expression in colorectal cancer.

The purpose of this study was to find a methylation-related gene that could become a biomarker or therapeutic target in colorectal carcinoma (CRC). We screened candidate genes suspected to be silenced by DNA methylation using cDNA microarray analysis. To investigate the clinical significance of one candidate gene (UNC5B), we analyzed the correlation between mRNA expression and clinicopathological features using clinical tissue samples.

Clinical significance of lymph node ratio and location of nodal involvement in patients with right colon cancer.

Background/aims: Increasing negative lymph node count has been reported to be associated with better outcomes in patients with colon cancer. The present study aimed to clarify the clinical significance of the lymph node ratio (LNR) and location of lymph node metastasis (LNM) in patients with stage III right colon cancer.

Methods: We enrolled 820 patients who had undergone curative resection due to colon cancer at a single institution between 1991 and 2005.

[Curative resection for bulky rectal gastrointestinal stromal tumor after neoadjuvant imatinib mesylate].

Gastrointestinal stromal tumor is the most common mesenchymal tumor of the gastrointestinal tract. However, the frequency of rectal gastrointestinal stromal tumor is relatively low. We described the case of a 54-year-old man with bulky rectal gastrointestinal stromal tumor of which a diameter was 10 cm.

[Clinicopathological studies and patterns of recurrence of mucinous colorectal carcinoma with curative resection].

In 771 cases of Stage II and III colorectal carcinoma with curative resection, clinicopathological characteristics, recurrent rate, patterns of recurrence, and prognosis of 24 cases (3%) of mucinous carcinoma were compared with those of 725 cases (94%) of well-moderately differentiated adenocarcinoma. Compared with well-moderately differentiated adenocarcinoma, mucinous carcinoma was found to be larger in tumor size, more severe lymphatic invasion, and a greater likelihood of Stage IIIb. Mucinous carcinoma had a highly recurrent rate and poorer prognosis than well-moderately differentiated adenocarcinoma.

[A case of colon cancer with multiple liver metastases effectively treated with hepatic arterial infusion followed by systemic chemotherapy].

A 63-year-old female was diagnosed as descending colon cancer with severe liver dysfunction caused by multiple liver metastases. Her performance status (PS) was 3 because of liver dysfunction and high fever. Initially, hepatic arterial infusion (HAI) chemotherapy was started to reduce the size of metastatic tumors and to prevent a liver failure.

[A case of unresectable and multiple advanced primary cancers of the stomach and rectosigmoid colon with hepatic metastases successfully treated with FOLFIRI for local control of a gastric lesion].

The patient was a 59-year-old man who was hospitalized at our department for intestinal obstruction. Contrast enhanced abdominal CT showed a rectosigmoid tumor invading the left pelvic wall and multiple metastatic hepatic tumors. Colonoscopy showed a type-2 cancer in the rectosigmoid region.

Effect of classification based on combination of mutation and methylation in colorectal cancer prognosis.

Colorectal cancer (CRC) is caused by an accumulation of genetic alterations and epigenetic alterations. The molecular classification of CRCs based on genetic alterations and epigenetic alterations is evolving. Here, we examined mutations and methylation status in CRCs to determine if the combination of genetic and epigenetic alterations predicts prognosis.

Validation and clinical use of the Japanese classification of colorectal carcinomatosis: benefit of surgical cytoreduction even without hyperthermic intraperitoneal chemotherapy.

Background: This study aimed to validate an easy to use practical classification of peritoneal metastasis arising from colorectal cancer.

Patients And Methods: Data from 2,134 consecutive patients who underwent resection for colorectal cancer at a single institution were reviewed. Peritoneal metastasis was classified depending on extent into three groups (P1-P3).

Methylated BNIP3 gene in colorectal cancer prognosis.

The DNA methylation of apoptosis-related genes in various cancers contributes to the disruption of the apoptotic pathway and results in resistance to chemotherapeutic agents. Irinotecan (CPT-11) is one of the key chemotherapy drugs used to treat metastatic colorectal cancer (CRC). However, a number of metastatic CRC patients do not benefit from this drug.

[A case of advanced rectal cancer with severe liver dysfunction due to multiple liver metastases].

We report a case of rectal cancer with unresectable multiple liver metastases, which was worried about the transition from liver dysfunction to liver failure. The male patient in his 70s was diagnosed as advanced rectal cancer with severe liver dysfunction because of multiple liver metastases. Hepatic arterial infusion (HAI) chemotherapy, which was effective to reduce the size of metastatic liver tumors, was initially started.

[A case of rectal cancer successfully treated by multidisciplinary strategy for liver and pulmonary metastases].

We report a case of rectal cancer with distant metastases, which was successfully treated with multidisciplinary treatments. The 60s female underwent an abdomino-perineal resection (APR) for low rectal cancer. One year after the APR, two hepatic metastases were found and initially treated by radiofrequency ablation and later by hepatectomy.

[A case of rectal cancer with lung metastases responding to cetuximab].

We report a 73-year-old male patient who underwent low anterior resection for rectal cancer (Stage IIIb). Nine months after the surgery, multiple metastases of liver, lung, brain and lymph node were detected. He was treated with FOLFOX4 and FOLFIRI though lung metastases progressed and caused dyspnea.

Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis.

Several new drugs that are targeted towards various angiogenic factors have shown considerable potential for controlling tumor proliferation and metastases. Expression levels of the targeted genes in primary tumors and metastases should be understood to maximize the use of such drugs. The present study aimed to clarify associations between mRNA levels of cyclooxygenase 2 (COX-2) and angiogenic factors [vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)] in primary colorectal cancer and in corresponding liver metastasis.