Publications by authors named "Tetsuo Kume"
Purpose: Hand-foot syndrome (HFS) is a typical skin disorder caused by the use of cytotoxic anticancer drugs and molecular targets. Similarly, various anticancer drugs have been used as a conditioning regimen for hematopoietic stem cell transplantation (HSCT), and skin disorders such as HFS have been reported. The aim of this study was to determine retrospectively the frequency of HFS in recipients who have received a first allogeneic HSCT and the risk factors for HFS occurrence.
View Article and Find Full Text PDFArticle Synopsis
- This study explored a nutritional support pathway for patients undergoing hematopoietic stem cell transplantation (HSCT), focusing on pre-conditioning education and oral nutrition to manage nutrition-related issues.
- It compared outcomes between a control group (46 patients) and an enhanced nutrition group (36 patients), measuring factors like body weight loss, skeletal muscle mass loss, and energy expenditure before and after nutritional intervention.
- Results showed that the enhanced nutrition group had better energy intake and weight management, suggesting that this approach could positively influence recovery post-HSCT without increasing gastrointestinal graft versus host disease severity.
Purpose: Busulfan is used as a conditioning regimen for hematopoietic stem cell transplantation and is known to cause seizures as a side effect. As various anticonvulsant drugs have been reported, we conducted a retrospective investigation regarding the preventive effects and adverse events associated with different anticonvulsants administered alongside intravenous busulfan (ivBu) in our institution.
Methods: We targeted 104 patients who received ivBu at our institution from May 1, 2010 to April 30, 2017.
Comparison of Nutrition-Related Adverse Events and Clinical Outcomes Between ICE (Ifosfamide, Carboplatin, and Etoposide) and MCEC (Ranimustine, Carboplatin, Etoposide, and Cyclophosphamide) Therapies as Pretreatment for Autologous Peripheral Blood Stem Cell Transplantation in Patients with Malignant Lymphoma.
Med Sci Monit Basic Res
February 2018
Article Synopsis
- The study compared the effectiveness of two chemotherapy regimens, ICE therapy and MCEC therapy, in patients receiving autologous stem cell transplants between 2007 and 2012, focusing on nutrition-related adverse events and clinical outcomes.
- Results showed that the ICE therapy group had better oral caloric intake and shorter hospital stays compared to the MCEC group, although it also led to delays in engraftment.
- Despite these improvements in nutrition and hospital stay, both therapies showed no significant difference in five-year survival rates, suggesting ICE therapy may optimize resource use without enhancing long-term outcomes.