Publications by authors named "Tetsujo Sujaku"
Background: Immune globulin intravenous (IGIV), 10% is a donor-derived polyclonal human immunoglobulin G antibody mixture that has potent immune modulatory properties and contains conformation selective anti-amyloid antibodies. We evaluated the safety and tolerability of multiple doses of IGIV, 10% in Japanese patients with mild to moderate Alzheimer's disease.
Methods: Among the 16 subjects, 12 subjects were assigned to the IGIV group and 4 subjects to the placebo group.
The behavioral assessment of pain is essential for the analysis of pain mechanisms and the evaluation of analgesic drugs. The formalin test is one of such methods widely used as a model of injury-induced pain in rodents. This test is manually demanding and the recording of results is left to the subjectivity of the experimenters.
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- The study investigates the solution-precipitation method using DMSO in drug discovery, focusing on the solid form of precipitates.
- Findings show that when the precipitates are crystalline and given enough time (20 hours), their solubility matches that of powdered materials.
- An automated birefringence diagnosis system was also developed to enhance the analysis of precipitates in drug discovery.
A novel kappa opioid receptor binding inhibitor CJ-15,208 (I) was isolated from the fermentation broth of a fungus, Ctenomyces serratus ATCC15502. The structure of I was determined to be a cyclic tetrapeptide consisting of one tryptophan, one D-proline, and two L-phenylalanine. Compound I was a selective binding inhibitor for the kappa opioid receptor: 47 nM (IC50) for kappa, 260 nM for mu, and 2,600 nM for delta.
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