Publications by authors named "Tetsu Wakimoto"

Background: Cervical polyps removed during pregnancy have been reported to be associated with preterm birth; however, the association between unremoved cervical polyps and preterm birth has not been elucidated.

Objective: This study aimed to clarify the relationship between cervical polyps detected before 12 weeks of gestation managed expectantly and spontaneous preterm birth.

Study Design: This retrospective cohort study included pregnant women who visited a tertiary perinatal center before 12 weeks of gestation between January 2015 and December 2019.

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Article Synopsis
  • The study aimed to investigate the link between the MTHFR C677T gene variation and specific pathologies in patients experiencing pregnancy loss.
  • Researchers analyzed data from 243 patients, assessing factors like age, BMI, and the presence of certain types of fibrin and thrombosis related to pregnancy loss, while also determining the patients' MTHFR C677T genotypes.
  • Findings revealed that carriers of the T allele and TT genotype had a higher likelihood of severe intervillous and decidual pathologies, suggesting that genetic variations could influence treatment strategies for those suffering pregnancy loss.
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Purpose: Necrotizing enterocolitis (NEC) is a devastating inflammatory disease of preterm infants that may depend on overexpression of toll-like receptor-4 (TLR4) in the immature intestine. Surfactant protein (SP)-D is a member of the collectin family and plays an important role in innate immunity, particularly in the airways. Although SP-D also exists in the intestines, little is known about its function.

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Article Synopsis
  • Intrauterine infections, specifically by bacteria like Escherichia coli and Ureaplasma spp, can lead to preterm birth by causing placental inflammation; this study tested a substance called hydroxylated fullerene (C60[OH]44) for its anti-inflammatory and antioxidant properties against such infections.
  • Laboratory experiments using cell lines and mouse macrophages showed that C60(OH)44 significantly reduced inflammation and oxidative stress caused by Ureaplasma's TLR2 ligand, UPM-1.
  • In a mouse model, C60(OH)44 also substantially lowered the preterm birth rate from 72.7% to 18.2%, indicating its potential as a preventive treatment
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Ureaplasma spp. cause several disorders, such as nongonococcal urethritis, miscarriage, and preterm delivery with lung infections in neonates, characterized by pathological chorioamnionitis in the placenta. Although reports on antibiotic resistance in Ureaplasma are on the rise, reports on quinolone-resistant Ureaplasma infections in Japan are limited.

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Ureaplasma spp. are members of the family Mycoplasmataceae and have been considered to be associated with chorioamnionitis and preterm delivery. However, it is unclear whether Ureaplasma spp.

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Malignant transformation is rarely seen in the disease course of mature cystic teratoma (MCT) of the ovary. Adenocarcinoma arising from MCT is especially rare. We herein present the case of a premenopausal woman with a mucinous borderline-like tumor arising from a MCT.

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