Effect of a large-sized silicone sheet upon recovery of mastoid aeration after mastoidectomy.

Objective: To evaluate the effect of our large-sized silicone sheet upon postoperative recovery of mastoid aeration in ears after surgery including mastoidectomy and soft-wall reconstruction (SWR).

Study Design And Setting: Retrospective chart review in a tertiary care center.

Subjects And Methods: Recovery of mastoid aeration was assessed by CT 4 to 12 months after surgery on 72 ears (69 patients), in which the silicone sheet covering from the eustachian tube (ET) to the mastoid was placed after SWR procedure with mastoidectomy were done for their chronic otitis media.

Influence of topical application of basic fibroblast growth factor upon inner ear.

Background: Basic fibroblast growth factor (b-FGF) has recently been shown to have a positive effect on the treatment of postoperative mastoid cavity problem, but its ototoxicity has not been investigated.

Objective: To investigate the effect of b-FGF on the inner ear of guinea pigs.

Study Design And Setting: In groups A (n = 10) and B (n =11), b-FGF was applied into the left external auditory canal and the middle ear, respectively.

Mastoid obliteration combined with soft-wall reconstruction of posterior ear canal.

To clarify the usefulness of modified soft-wall reconstruction method by combing with mastoid obliteration, 96 patients (98 ears) with their age ranging from 5 to 82 (average 51.3), including 62 ears with chronic otitis media (COM) with cholesteatoma, 18 ears with non-cholesteatomatous COM, 14 ears with postoperative cavity problem, and 4 ears with adhesive-type COM, who had soft-wall reconstruction of the posterior ear canal and mastoid obliteration using mainly bone powder following mastoidectomy, were evaluated their postoperative conditions more than a year after surgery. Overall success rate was 76.

Does topical application of 5-fluorouracil ointment influence inner ear function?

Objective: To investigate the effect of 5-fluorouracil (5-FU) ointment on the inner ear of guinea pigs.

Study Design And Setting: In group A (n = 7), 5-FU ointment was applied into the left external auditory canal. In group B (n = 10), 5-FU ointment was applied to the left middle ear through myringotomy.

Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma.

Objective: In order to clarify clinical efficacy of commercially available 5-fluorouracil (5-FU) topical cream, a clinical study was conducted.

Methods: Two to three cubic millimetres of 5-FU topical cream (Kyowa, Roche) was applied on 50 cases of various types of cholesteatoma (50 patients) two to five times with the interval of 2 weeks, and its clinical efficacy was evaluated by the criteria we developed.

Results: In total, 59% of the cholesteatomas showed good effect, 29% of them showed fair effect, and the effect was poor in the remaining 12%.